Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 626375..627016 Replicon chromosome
Accession NZ_CP029185
Organism Limnobaculum parvum strain HYN0051

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag HYN51_RS02210 Protein ID WP_108901346.1
Coordinates 626375..626557 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag HYN51_RS02215 Protein ID WP_108901347.1
Coordinates 626576..627016 (+) Length 147 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HYN51_RS02180 621507..622913 + 1407 WP_108901340.1 PTS ascorbate transporter subunit IIC -
HYN51_RS02185 622932..623237 + 306 WP_108901341.1 PTS ascorbate transporter subunit IIB -
HYN51_RS02190 623247..623705 + 459 WP_108901342.1 PTS ascorbate transporter subunit IIA -
HYN51_RS02195 623753..624409 + 657 WP_108901343.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
HYN51_RS02200 624419..625279 + 861 WP_108901344.1 L-ribulose-5-phosphate 3-epimerase -
HYN51_RS02205 625279..625968 + 690 WP_108901345.1 L-ribulose-5-phosphate 4-epimerase -
HYN51_RS02210 626375..626557 + 183 WP_108901346.1 type II toxin-antitoxin system HicA family toxin Toxin
HYN51_RS02215 626576..627016 + 441 WP_108901347.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
HYN51_RS02220 627060..627989 - 930 WP_108901348.1 2-dehydropantoate 2-reductase -
HYN51_RS02225 628225..628941 + 717 WP_108901349.1 phosphatase PAP2 family protein -
HYN51_RS02230 628966..629553 + 588 WP_108901350.1 undecaprenyl-diphosphate phosphatase -
HYN51_RS02235 630010..631320 + 1311 WP_108901351.1 collagen-like triple helix repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-137)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6803.92 Da        Isoelectric Point: 11.4114

>T105178 WP_108901346.1 NZ_CP029185:626375-626557 [Limnobaculum parvum]
MKSSDLIKELRAAGCEWRRHNGGSHQIWWSPITKKTFPVPHPKKNLPEGTVRSIKRAAGI

Download         Length: 183 bp

>T105178 NZ_CP029185:626375-626557 [Limnobaculum parvum]
ATGAAATCATCGGATTTGATTAAAGAACTTCGGGCTGCTGGGTGTGAATGGCGGCGGCATAATGGAGGAAGCCACCAGAT
ATGGTGGTCTCCGATAACGAAAAAAACATTTCCAGTCCCTCATCCTAAAAAGAATTTGCCTGAGGGCACCGTTAGATCGA
TCAAAAGAGCGGCTGGAATTTAG

Antitoxin


Download         Length: 147 a.a.        Molecular weight: 16442.66 Da        Isoelectric Point: 4.2618

>AT105178 WP_108901347.1 NZ_CP029185:626576-627016 [Limnobaculum parvum]
MLFSIAVEVPQDEQTAYGLTVPALCNEDYGCFSAADCVEDVAGMAREAILLTITDMIESGRYSLAQIKDLGPLVYQKTHT
EFDGQQWFVIEVDLSELEGKPQRINISLPDVLIRRIDSRVKTQDDYRDRSHFLAVAAKNELLRMEG

Download         Length: 441 bp

>AT105178 NZ_CP029185:626576-627016 [Limnobaculum parvum]
ATGTTATTTTCTATTGCTGTTGAAGTACCACAAGATGAGCAGACGGCTTATGGTCTAACTGTGCCTGCTTTATGTAACGA
AGATTATGGCTGTTTTTCTGCGGCAGACTGCGTAGAAGATGTGGCCGGAATGGCCCGGGAGGCCATTTTACTCACCATCA
CTGATATGATTGAATCAGGGCGCTATTCTTTAGCGCAAATTAAAGATCTTGGTCCGTTGGTTTATCAGAAAACCCATACT
GAATTTGATGGACAACAATGGTTTGTGATTGAGGTTGATTTGTCGGAGCTGGAAGGAAAACCACAGCGGATTAATATTTC
GCTACCGGATGTGTTAATTCGTCGAATTGATTCACGTGTTAAAACTCAGGATGATTACCGCGACCGTAGCCATTTTCTGG
CCGTTGCGGCAAAAAATGAATTATTAAGGATGGAAGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References