Detailed information of TA system TA105149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 28702..29255
• Replicon: plasmid unnamed1
• Accession: NZ_CP029177
• Organism: Acidibrevibacterium fodinaquatile strain G45-3

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: DEF76_RS18630
• Protein ID: WP_114914019.1
• Coordinates: 28962..29255 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: DEF76_RS18625
• Protein ID: WP_114914018.1
• Coordinates: 28702..28974 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEF76_RS18600	24580..25539	-	960	WP_114914016.1	ABC transporter substrate-binding protein	-
DEF76_RS18605	26487..27365	+	879	WP_114914046.1	NAD(P)-dependent oxidoreductase	-
DEF76_RS18610	27375..27551	-	177	Protein_30	transposase	-
DEF76_RS18615	27570..27884	-	315	WP_162800769.1	integrase core domain-containing protein	-
DEF76_RS18620	27862..28167	-	306	Protein_32	IS21 family transposase	-
DEF76_RS18625	28702..28974	+	273	WP_114914018.1	CopG family ribbon-helix-helix protein	Antitoxin
DEF76_RS18630	28962..29255	+	294	WP_114914019.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DEF76_RS18640	29589..30188	+	600	WP_114914021.1	hypothetical protein	-
DEF76_RS18645	30499..32523	+	2025	WP_114914022.1	sigma-54-dependent Fis family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..68344	68344
	-	flank	IS/Tn	-	-	27796..28167	371

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11096.78 Da
• Isoelectric Point: 9.5400

>T105149 WP_114914019.1 NZ_CP029177:28962-29255 [Acidibrevibacterium fodinaquatile]
VPRIIVTEGGVRDLERCRHYLRQRSLEAARRAARVIAQRFSQLAIHPALGRPVPDTPELRELIIPFGDAGYVVLYRHEPV
DDAVYILAVRHQREAGY

Nucleotide

• Length: 294 bp

>T105149 NZ_CP029177:28962-29255 [Acidibrevibacterium fodinaquatile]
GTGCCACGAATAATCGTCACCGAAGGGGGCGTGCGGGATCTCGAGCGGTGCCGGCACTATTTGCGCCAACGCAGCCTCGA
AGCGGCCCGGCGGGCAGCTCGCGTGATCGCGCAGCGGTTCTCACAGCTTGCAATTCATCCCGCGCTCGGCAGACCTGTCC
CGGACACCCCGGAGTTGCGCGAACTGATAATACCGTTCGGAGATGCCGGCTATGTCGTGCTCTATCGCCATGAGCCGGTC
GATGACGCGGTCTATATCCTCGCGGTCCGCCACCAGCGGGAGGCGGGATACTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10526.71 Da
• Isoelectric Point: 5.1991

>AT105149 WP_114914018.1 NZ_CP029177:28702-28974 [Acidibrevibacterium fodinaquatile]
MITSIKLDDNLASRIRRLAELRRRSAHWIMREAIRDYVVREEARESFRQEALASWSAFQDTGRHLTGEEVQAWLTSWGSD
AEAEPPECHE

Nucleotide

• Length: 273 bp

>AT105149 NZ_CP029177:28702-28974 [Acidibrevibacterium fodinaquatile]
ATGATCACCTCGATCAAACTCGATGACAATCTTGCCAGCCGGATCCGCCGGCTCGCCGAACTCCGGCGGCGCTCGGCGCA
TTGGATCATGCGTGAGGCCATCCGCGACTACGTCGTTCGTGAGGAGGCGCGCGAGAGCTTCCGCCAGGAAGCTCTGGCCT
CCTGGTCGGCCTTCCAGGATACTGGCCGCCACCTGACCGGCGAGGAAGTGCAAGCGTGGTTGACCTCCTGGGGGAGTGAT
GCCGAGGCAGAGCCGCCTGAGTGCCACGAATAA