Detailed information of TA system TA105148

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 3012023..3012685
• Replicon: chromosome
• Accession: NZ_CP029176
• Organism: Acidibrevibacterium fodinaquatile strain G45-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DEF76_RS14330
• Protein ID: WP_114912913.1
• Coordinates: 3012281..3012685 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DEF76_RS14325
• Protein ID: WP_114912912.1
• Coordinates: 3012023..3012280 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEF76_RS14315	3008404..3009156	+	753	WP_114912091.1	IS21-like element helper ATPase IstB	-
DEF76_RS14320	3009281..3011950	+	2670	WP_205216009.1	DUF3883 domain-containing protein	-
DEF76_RS14325	3012023..3012280	+	258	WP_114912912.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
DEF76_RS14330	3012281..3012685	+	405	WP_114912913.1	type II toxin-antitoxin system VapC family toxin	Toxin
DEF76_RS14335	3012682..3013113	+	432	WP_114912914.1	hypothetical protein	-
DEF76_RS14340	3013116..3014414	+	1299	WP_162800762.1	hypothetical protein	-
DEF76_RS19705	3014433..3015752	+	1320	Protein_2828	DUF1156 domain-containing protein	-
DEF76_RS19710	3015744..3016343	+	600	Protein_2829	transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2995873..3167987	172114

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-122)

Antitoxin

• Antitoxin VapB-like (1-82)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14330.40 Da
• Isoelectric Point: 6.2237

>T105148 WP_114912913.1 NZ_CP029176:3012281-3012685 [Acidibrevibacterium fodinaquatile]
MVVDTSALVAILLGEPDAERFARALSAAPVRLISAVTRVELSFVIGSRKGETGRADLELLLRDGGFDVVSVTPQQATIAI
EAFRRYGRGRHRAGLNIGDCFSYALAVATDHPLLFKGDDFIHTDLQPALPASAP

Nucleotide

• Length: 405 bp

>T105148 NZ_CP029176:3012281-3012685 [Acidibrevibacterium fodinaquatile]
ATGGTTGTCGATACCTCGGCGCTGGTCGCGATCTTGCTCGGCGAGCCTGACGCCGAGCGCTTCGCGCGCGCGTTGAGCGC
GGCACCGGTGCGGCTGATCTCCGCGGTCACACGGGTGGAGCTTTCCTTCGTCATCGGGAGTCGCAAGGGCGAGACGGGTC
GCGCGGACCTTGAGCTGCTGCTGCGCGATGGCGGCTTCGACGTCGTCAGCGTCACGCCGCAGCAGGCGACGATCGCCATC
GAGGCTTTCCGTCGCTACGGACGCGGCCGTCATCGCGCCGGGCTGAACATTGGCGACTGCTTTTCCTACGCGCTGGCCGT
GGCGACCGACCATCCGCTGCTGTTCAAAGGCGATGATTTTATCCATACCGATCTGCAACCGGCCCTGCCGGCATCCGCGC
CATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9661.04 Da
• Isoelectric Point: 8.0204

>AT105148 WP_114912912.1 NZ_CP029176:3012023-3012280 [Acidibrevibacterium fodinaquatile]
MALSLKNKETDRLAREVAALTGETLTDAIRKALAERLERERLRRGGTLRLADRLMEIGRHCASLPDRDPRSPDEIVGYDE
AGMWR

Nucleotide

• Length: 258 bp

>AT105148 NZ_CP029176:3012023-3012280 [Acidibrevibacterium fodinaquatile]
TTGGCGCTGAGCCTGAAGAACAAAGAGACCGACCGCCTCGCCCGCGAGGTCGCCGCTCTGACGGGCGAGACGCTGACGGA
CGCGATCCGCAAGGCGCTGGCCGAACGGCTGGAGCGCGAGCGCCTGCGCCGGGGCGGAACGCTGCGGCTTGCCGATCGGC
TGATGGAGATCGGCCGCCACTGCGCTTCCTTGCCCGACCGCGATCCCCGCAGCCCGGATGAGATCGTCGGCTACGACGAA
GCCGGCATGTGGCGCTGA