Detailed information of TA system TA105147

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 2745062..2745758
• Replicon: chromosome
• Accession: NZ_CP029176
• Organism: Acidibrevibacterium fodinaquatile strain G45-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DEF76_RS13075
• Protein ID: WP_114912717.1
• Coordinates: 2745309..2745758 (+)
• Length: 150 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DEF76_RS13070
• Protein ID: WP_114912716.1
• Coordinates: 2745062..2745304 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEF76_RS19395	2740695..2740982	-	288	WP_162800640.1	hypothetical protein	-
DEF76_RS19400	2741308..2741547	+	240	WP_162800535.1	hypothetical protein	-
DEF76_RS13050	2741773..2742048	+	276	WP_114911783.1	hypothetical protein	-
DEF76_RS13055	2742149..2743933	+	1785	WP_114912713.1	recombinase family protein	-
DEF76_RS13060	2743985..2744407	-	423	WP_114912714.1	type II toxin-antitoxin system VapC family toxin	-
DEF76_RS13065	2744407..2744652	-	246	WP_114912715.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
DEF76_RS19405	2744882..2745028	+	147	WP_162800641.1	hypothetical protein	-
DEF76_RS13070	2745062..2745304	+	243	WP_114912716.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DEF76_RS13075	2745309..2745758	+	450	WP_114912717.1	type II toxin-antitoxin system VapC family toxin	Toxin
DEF76_RS13080	2745999..2746601	+	603	WP_162800642.1	TIGR02584 family CRISPR-associated protein	-
DEF76_RS13085	2746636..2747519	+	884	Protein_2581	IS3 family transposase	-
DEF76_RS13090	2747697..2749238	+	1542	WP_114911000.1	IS21 family transposase	-
DEF76_RS13095	2749260..2749946	+	687	WP_114912719.1	IS21-like element helper ATPase IstB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2716843..2768009	51166

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-125)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 150 a.a.
• Molecular weight: 16091.50 Da
• Isoelectric Point: 7.2010

>T105147 WP_114912717.1 NZ_CP029176:2745309-2745758 [Acidibrevibacterium fodinaquatile]
MYLVDTNVISGRAPARVAPAEMTAWMDAHSEKLFLSVVTIAEIEDGIAKAKREGAARKSRDLSAWLETVLHLYAARILPF
DIATARLAGALSDFARSQGHAPGFADIVIAATAQHHGLIILTRNLRHFAPLGVPAHDPFAHPPQNMAPE

Nucleotide

• Length: 450 bp

>T105147 NZ_CP029176:2745309-2745758 [Acidibrevibacterium fodinaquatile]
TTGTACCTCGTCGACACCAATGTCATTTCGGGGCGCGCGCCTGCACGGGTAGCGCCTGCCGAGATGACCGCCTGGATGGA
TGCGCACTCCGAGAAGCTATTCCTCTCGGTTGTGACCATCGCGGAAATCGAGGACGGCATCGCCAAGGCCAAACGAGAAG
GCGCCGCTCGCAAATCCCGAGACCTGAGCGCATGGCTCGAAACGGTATTGCACCTCTATGCTGCCCGCATCCTGCCTTTT
GATATCGCAACCGCCCGTCTCGCTGGTGCCCTGTCGGATTTCGCTCGCAGCCAGGGTCACGCGCCCGGCTTCGCGGATAT
CGTGATTGCTGCGACCGCCCAGCACCACGGGCTCATCATCCTTACCCGCAACCTGCGACATTTTGCGCCGCTCGGCGTCC
CAGCGCACGACCCATTTGCACACCCGCCCCAAAATATGGCTCCAGAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8771.13 Da
• Isoelectric Point: 10.7342

>AT105147 WP_114912716.1 NZ_CP029176:2745062-2745304 [Acidibrevibacterium fodinaquatile]
MREIQLRDAKASLSAVVADARRGEAAIITRHGKPEAVILGFEEWQRLSHVPSFGKLLMAAPLEKGDLPRRNTAPPRDSGL

Nucleotide

• Length: 243 bp

>AT105147 NZ_CP029176:2745062-2745304 [Acidibrevibacterium fodinaquatile]
ATGCGAGAAATCCAGCTCCGCGACGCCAAGGCCAGCCTCTCCGCCGTCGTCGCCGACGCCCGACGTGGGGAGGCCGCCAT
CATCACACGCCACGGTAAGCCTGAGGCGGTCATTTTGGGGTTCGAGGAATGGCAGCGCCTCTCGCACGTGCCATCTTTTG
GTAAGTTGCTGATGGCGGCTCCCCTCGAAAAGGGGGATTTGCCGCGACGCAACACCGCCCCTCCCCGCGACAGCGGACTC
TGA