Detailed information of TA system TA105146

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-Phd
• Location: 1529903..1530599
• Replicon: chromosome
• Accession: NZ_CP029176
• Organism: Acidibrevibacterium fodinaquatile strain G45-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DEF76_RS07370
• Protein ID: WP_114911778.1
• Coordinates: 1529903..1530352 (-)
• Length: 150 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DEF76_RS07375
• Protein ID: WP_114912716.1
• Coordinates: 1530357..1530599 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEF76_RS07350	1524939..1526072	-	1134	WP_162800534.1	acyltransferase	-
DEF76_RS07355	1526254..1527771	+	1518	WP_114911775.1	glycosyltransferase family 39 protein	-
DEF76_RS07360	1528063..1528452	-	390	WP_114911776.1	type II toxin-antitoxin system VapC family toxin	-
DEF76_RS07365	1528449..1528697	-	249	WP_114911777.1	type II toxin-antitoxin system VapB family antitoxin	-
DEF76_RS07370	1529903..1530352	-	450	WP_114911778.1	type II toxin-antitoxin system VapC family toxin	Toxin
DEF76_RS07375	1530357..1530599	-	243	WP_114912716.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DEF76_RS07380	1530763..1531104	-	342	WP_114911779.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DEF76_RS07385	1531077..1531364	-	288	WP_114911780.1	type II toxin-antitoxin system ParD family antitoxin	-
DEF76_RS07390	1531543..1532892	-	1350	WP_114911781.1	recombinase family protein	-
DEF76_RS07400	1533430..1533705	-	276	WP_114911783.1	hypothetical protein	-
DEF76_RS19265	1533931..1534170	-	240	WP_162800535.1	hypothetical protein	-
DEF76_RS19680	1534963..1535577	+	615	WP_205216133.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1528063..1537968	9905

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-126)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-52)

Sequences

Toxin

Protein

• Length: 150 a.a.
• Molecular weight: 16208.56 Da
• Isoelectric Point: 6.9234

>T105146 WP_114911778.1 NZ_CP029176:c1530352-1529903 [Acidibrevibacterium fodinaquatile]
MYLVDTNVISERAPARVAPAEMTAWMDAHSEKLFLSVVTIAEIEDGIAKAKREGAARKSRDLSAWLETVLHLYAARILPF
DIATARLAGALSDFARSQGHAPGFADIVIAATAQHHGLIILTRNQRHFAPLGVPTHDPFAHPPQNMAPE

Nucleotide

• Length: 450 bp

>T105146 NZ_CP029176:c1530352-1529903 [Acidibrevibacterium fodinaquatile]
TTGTACCTCGTCGACACCAATGTCATTTCGGAGCGCGCGCCTGCACGGGTAGCGCCTGCCGAGATGACCGCCTGGATGGA
TGCGCACTCCGAGAAGCTATTCCTCTCGGTTGTGACCATCGCGGAAATCGAGGACGGCATCGCCAAGGCCAAACGAGAAG
GCGCCGCTCGCAAATCCCGAGACCTGAGCGCATGGCTCGAAACGGTATTGCACCTCTATGCTGCCCGCATCCTGCCTTTT
GATATCGCAACCGCCCGTCTCGCTGGTGCCCTGTCGGATTTCGCTCGCAGCCAGGGTCACGCGCCCGGCTTCGCGGATAT
CGTGATTGCTGCGACCGCCCAGCACCACGGGCTCATCATCCTTACCCGCAACCAGCGACATTTTGCGCCGCTCGGCGTCC
CAACGCACGACCCATTTGCACACCCACCCCAAAATATGGCTCCAGAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8771.13 Da
• Isoelectric Point: 10.7342

>AT105146 WP_114912716.1 NZ_CP029176:c1530599-1530357 [Acidibrevibacterium fodinaquatile]
MREIQLRDAKASLSAVVADARRGEAAIITRHGKPEAVILGFEEWQRLSHVPSFGKLLMAAPLEKGDLPRRNTAPPRDSGL

Nucleotide

• Length: 243 bp

>AT105146 NZ_CP029176:c1530599-1530357 [Acidibrevibacterium fodinaquatile]
ATGCGAGAAATCCAGCTCCGCGACGCCAAGGCCAGCCTCTCCGCCGTCGTCGCCGACGCCCGACGTGGGGAGGCCGCCAT
CATCACACGCCACGGTAAGCCTGAGGCGGTCATTTTGGGGTTCGAGGAATGGCAGCGCCTCTCGCACGTGCCATCTTTTG
GTAAGTTGCTGATGGCGGCTCCCCTCGAAAAGGGGGATTTGCCGCGACGCAACACCGCCCCTCCCCGCGACAGCGGACTC
TGA