Detailed information of TA system TA105145

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1528063..1528697
• Replicon: chromosome
• Accession: NZ_CP029176
• Organism: Acidibrevibacterium fodinaquatile strain G45-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DEF76_RS07360
• Protein ID: WP_114911776.1
• Coordinates: 1528063..1528452 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DEF76_RS07365
• Protein ID: WP_114911777.1
• Coordinates: 1528449..1528697 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEF76_RS07350	1524939..1526072	-	1134	WP_162800534.1	acyltransferase	-
DEF76_RS07355	1526254..1527771	+	1518	WP_114911775.1	glycosyltransferase family 39 protein	-
DEF76_RS07360	1528063..1528452	-	390	WP_114911776.1	type II toxin-antitoxin system VapC family toxin	Toxin
DEF76_RS07365	1528449..1528697	-	249	WP_114911777.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
DEF76_RS07370	1529903..1530352	-	450	WP_114911778.1	type II toxin-antitoxin system VapC family toxin	-
DEF76_RS07375	1530357..1530599	-	243	WP_114912716.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
DEF76_RS07380	1530763..1531104	-	342	WP_114911779.1	type II toxin-antitoxin system RelE/ParE family toxin	-
DEF76_RS07385	1531077..1531364	-	288	WP_114911780.1	type II toxin-antitoxin system ParD family antitoxin	-
DEF76_RS07390	1531543..1532892	-	1350	WP_114911781.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1528063..1537968	9905

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-81)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14187.13 Da
• Isoelectric Point: 4.6150

>T105145 WP_114911776.1 NZ_CP029176:c1528452-1528063 [Acidibrevibacterium fodinaquatile]
MIIDTSAMVAILYREPEAEAFTRLIHDADECRISVASYVELSIVVENQLGPEGMRLAEAFFRRAGVTVEPVTVEQGELAR
QAFLDFGKGRHKAGLNYGDCFPYALAKATGEPLLFKGNDFSQTDIRTAA

Nucleotide

• Length: 390 bp

>T105145 NZ_CP029176:c1528452-1528063 [Acidibrevibacterium fodinaquatile]
ATGATTATCGATACATCGGCAATGGTCGCCATCCTCTACCGCGAGCCTGAAGCGGAAGCCTTCACGCGGCTCATTCACGA
CGCCGACGAATGCCGCATCAGCGTGGCGAGCTATGTCGAGCTGTCAATAGTGGTCGAAAATCAGCTTGGCCCGGAGGGTA
TGCGGCTGGCTGAGGCATTCTTCCGCCGCGCCGGTGTCACGGTCGAGCCGGTAACGGTTGAGCAGGGCGAGCTGGCGCGG
CAGGCCTTCCTTGATTTTGGCAAGGGCAGGCACAAGGCTGGCCTGAATTACGGCGACTGCTTTCCCTATGCCCTGGCGAA
GGCCACGGGCGAACCGCTCTTATTTAAGGGTAATGACTTCAGCCAAACCGATATCAGGACGGCCGCGTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9141.44 Da
• Isoelectric Point: 9.9487

>AT105145 WP_114911777.1 NZ_CP029176:c1528697-1528449 [Acidibrevibacterium fodinaquatile]
MSLNIKDPEAHRLAQAISRATGESMTRVVTEALRERYAKIEQRKGKASVQELLAIADRAAAHVKRPYASHAELLYDENGL
PK

Nucleotide

• Length: 249 bp

>AT105145 NZ_CP029176:c1528697-1528449 [Acidibrevibacterium fodinaquatile]
ATGAGCCTCAACATCAAAGACCCCGAGGCACACCGTTTGGCGCAGGCTATCTCCCGCGCCACGGGCGAAAGCATGACACG
TGTCGTCACCGAGGCCCTGCGCGAACGTTACGCCAAGATTGAACAGCGAAAAGGCAAGGCCAGTGTACAAGAGCTGCTGG
CAATCGCCGATCGCGCCGCCGCCCATGTGAAGCGCCCTTACGCCAGCCATGCCGAGCTGCTCTATGACGAGAATGGTCTG
CCGAAATGA