Detailed information of TA system TA105144

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 561229..561902
• Replicon: chromosome
• Accession: NZ_CP029176
• Organism: Acidibrevibacterium fodinaquatile strain G45-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DEF76_RS02730
• Protein ID: WP_114911014.1
• Coordinates: 561480..561902 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DEF76_RS02725
• Protein ID: WP_114911013.1
• Coordinates: 561229..561483 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEF76_RS02710	558837..559895	+	1059	WP_114911011.1	toprim domain-containing protein	-
DEF76_RS02720	560214..561149	+	936	WP_114913616.1	DUF2493 domain-containing protein	-
DEF76_RS02725	561229..561483	+	255	WP_114911013.1	plasmid stabilization protein	Antitoxin
DEF76_RS02730	561480..561902	+	423	WP_114911014.1	type II toxin-antitoxin system VapC family toxin	Toxin
DEF76_RS02735	561962..564250	-	2289	WP_114911015.1	hypothetical protein	-
DEF76_RS02740	564636..565088	+	453	WP_114913617.1	hypothetical protein	-
DEF76_RS02745	565741..566064	+	324	WP_114911016.1	DUF736 domain-containing protein	-
DEF76_RS02750	566124..566369	-	246	WP_114911017.1	helix-turn-helix domain-containing protein	-
DEF76_RS02755	566535..566792	+	258	WP_114911018.1	DUF2285 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	535316..639909	104593

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 14840.19 Da
• Isoelectric Point: 5.8613

>T105144 WP_114911014.1 NZ_CP029176:561480-561902 [Acidibrevibacterium fodinaquatile]
MILLDTNVVSEAMKPEPAPAVRAWLDAQAAETLFLSSVTVAELMFGIGALPKGRRKDKLTAALDGVLDLFTDRILPFDTR
AARRYAELALRARAAGKGFPTPDGYIAAIAAAHDFAVVSRDTSAFVAAGVTVIDPWIAAV

Nucleotide

• Length: 423 bp

>T105144 NZ_CP029176:561480-561902 [Acidibrevibacterium fodinaquatile]
ATGATCCTGCTCGACACCAATGTCGTCTCCGAGGCGATGAAGCCCGAACCGGCGCCCGCCGTCCGCGCCTGGCTCGACGC
GCAGGCGGCAGAGACGCTCTTTCTCTCCAGCGTCACCGTCGCCGAGCTGATGTTCGGCATCGGCGCGCTACCCAAGGGGC
GCCGCAAGGACAAGCTGACCGCAGCACTCGATGGCGTGCTGGACCTGTTCACGGACCGCATCCTGCCGTTCGATACCCGC
GCGGCGCGCCGATACGCCGAACTCGCTCTCAGGGCGCGCGCCGCCGGAAAAGGCTTCCCGACGCCCGACGGCTATATCGC
CGCCATCGCCGCGGCACATGATTTCGCAGTCGTATCCCGCGACACGAGCGCGTTTGTCGCCGCTGGCGTCACCGTGATCG
ATCCATGGATAGCCGCAGTGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9333.60 Da
• Isoelectric Point: 11.1986

>AT105144 WP_114911013.1 NZ_CP029176:561229-561483 [Acidibrevibacterium fodinaquatile]
MPAVTIRNLSDETHRALKVRAAQHNRSTEAEMRAILDSAVRPQDRLRLGSALAEMSRKIGLTNADVEALDQSRNARPAEP
LRFA

Nucleotide

• Length: 255 bp

>AT105144 NZ_CP029176:561229-561483 [Acidibrevibacterium fodinaquatile]
ATGCCTGCTGTCACCATCCGCAATCTCTCCGACGAGACGCATCGCGCCCTGAAAGTCCGGGCGGCGCAGCACAATCGCAG
CACCGAGGCGGAAATGCGCGCCATCCTGGACAGTGCGGTACGGCCACAAGACCGGCTACGCCTCGGCTCCGCGCTGGCGG
AGATGAGCCGCAAGATCGGCCTCACCAACGCCGATGTCGAAGCCCTCGACCAGTCCCGCAACGCGAGGCCCGCCGAGCCA
TTGCGTTTCGCATGA