Detailed information of TA system TA105143

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 526463..527118
• Replicon: chromosome
• Accession: NZ_CP029176
• Organism: Acidibrevibacterium fodinaquatile strain G45-3

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: DEF76_RS02585
• Protein ID: WP_114910987.1
• Coordinates: 526720..527118 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: DEF76_RS02580
• Protein ID: WP_114910986.1
• Coordinates: 526463..526720 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEF76_RS02555	522153..523277	+	1125	WP_162800756.1	TrbI/VirB10 family protein	-
DEF76_RS02560	523288..523563	+	276	WP_114910983.1	DUF2274 domain-containing protein	-
DEF76_RS02565	523499..524419	-	921	WP_114910984.1	LysR family transcriptional regulator	-
DEF76_RS02570	524678..525964	-	1287	WP_114910985.1	site-specific integrase	-
DEF76_RS02580	526463..526720	+	258	WP_114910986.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
DEF76_RS02585	526720..527118	+	399	WP_114910987.1	type II toxin-antitoxin system VapC family toxin	Toxin
DEF76_RS02590	527128..528540	+	1413	WP_114910988.1	hypothetical protein	-
DEF76_RS02595	528545..529195	+	651	WP_114910989.1	hypothetical protein	-
DEF76_RS02600	529206..529880	+	675	WP_114910990.1	SOS response-associated peptidase	-
DEF76_RS02605	529893..532097	+	2205	WP_114910991.1	ATP-dependent RecD-like DNA helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (1-66)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 13893.87 Da
• Isoelectric Point: 6.2211

>T105143 WP_114910987.1 NZ_CP029176:526720-527118 [Acidibrevibacterium fodinaquatile]
MVVDSSALIALLLRTPDAARFDAALADAPVRLISAVTRAEVACVIESRKGAPGRTALERLLREGDIETAAVTPQQADLAA
DAAQRFGSGRHSAALTLGDCFAYALAQIVGLPLLFRDERFRHTDVTAALHGG

Nucleotide

• Length: 399 bp

>T105143 NZ_CP029176:526720-527118 [Acidibrevibacterium fodinaquatile]
ATGGTGGTCGATAGTTCGGCACTAATCGCCCTCCTGCTCCGGACACCGGATGCCGCCCGATTCGACGCCGCCCTCGCCGA
CGCACCAGTCCGTCTGATCTCGGCGGTGACCCGGGCCGAGGTCGCCTGCGTCATCGAGAGCCGCAAAGGCGCGCCCGGTC
GAACGGCCCTGGAACGGCTGTTGCGCGAGGGTGACATCGAGACCGCCGCGGTCACACCGCAGCAGGCGGACCTCGCTGCT
GATGCGGCCCAAAGGTTCGGCTCGGGCCGGCACTCGGCCGCACTGACCCTGGGCGATTGCTTTGCCTACGCCCTGGCCCA
GATCGTCGGCCTGCCCCTGCTGTTCAGGGACGAGCGGTTCCGGCACACGGATGTCACCGCCGCCCTGCACGGCGGATAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9057.40 Da
• Isoelectric Point: 11.4948

>AT105143 WP_114910986.1 NZ_CP029176:526463-526720 [Acidibrevibacterium fodinaquatile]
MALSLKDPETDHLARALAALAGETLTEAIRRALAERLARERIRRGHQGGLAGRIREIGEHCAALPDVASPATGAPPGRGA
ARMWR

Nucleotide

• Length: 258 bp

>AT105143 NZ_CP029176:526463-526720 [Acidibrevibacterium fodinaquatile]
ATGGCCCTTAGCCTGAAGGACCCTGAGACCGACCACCTCGCCCGGGCGCTGGCAGCGCTGGCCGGGGAGACGCTCACGGA
GGCGATCCGTAGGGCGTTGGCCGAGCGGCTGGCGCGCGAGCGGATCCGACGGGGCCATCAGGGCGGCCTCGCTGGCCGGA
TCCGCGAGATCGGCGAGCACTGTGCCGCGCTGCCCGACGTGGCCTCACCTGCGACGGGTGCACCGCCTGGACGTGGTGCC
GCAAGGATGTGGCGCTGA