Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 526463..527118 Replicon chromosome
Accession NZ_CP029176
Organism Acidibrevibacterium fodinaquatile strain G45-3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DEF76_RS02585 Protein ID WP_114910987.1
Coordinates 526720..527118 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DEF76_RS02580 Protein ID WP_114910986.1
Coordinates 526463..526720 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DEF76_RS02555 522153..523277 + 1125 WP_162800756.1 TrbI/VirB10 family protein -
DEF76_RS02560 523288..523563 + 276 WP_114910983.1 DUF2274 domain-containing protein -
DEF76_RS02565 523499..524419 - 921 WP_114910984.1 LysR family transcriptional regulator -
DEF76_RS02570 524678..525964 - 1287 WP_114910985.1 site-specific integrase -
DEF76_RS02580 526463..526720 + 258 WP_114910986.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
DEF76_RS02585 526720..527118 + 399 WP_114910987.1 type II toxin-antitoxin system VapC family toxin Toxin
DEF76_RS02590 527128..528540 + 1413 WP_114910988.1 hypothetical protein -
DEF76_RS02595 528545..529195 + 651 WP_114910989.1 hypothetical protein -
DEF76_RS02600 529206..529880 + 675 WP_114910990.1 SOS response-associated peptidase -
DEF76_RS02605 529893..532097 + 2205 WP_114910991.1 ATP-dependent RecD-like DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-66)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 13893.87 Da        Isoelectric Point: 6.2211

>T105143 WP_114910987.1 NZ_CP029176:526720-527118 [Acidibrevibacterium fodinaquatile]
MVVDSSALIALLLRTPDAARFDAALADAPVRLISAVTRAEVACVIESRKGAPGRTALERLLREGDIETAAVTPQQADLAA
DAAQRFGSGRHSAALTLGDCFAYALAQIVGLPLLFRDERFRHTDVTAALHGG

Download         Length: 399 bp

>T105143 NZ_CP029176:526720-527118 [Acidibrevibacterium fodinaquatile]
ATGGTGGTCGATAGTTCGGCACTAATCGCCCTCCTGCTCCGGACACCGGATGCCGCCCGATTCGACGCCGCCCTCGCCGA
CGCACCAGTCCGTCTGATCTCGGCGGTGACCCGGGCCGAGGTCGCCTGCGTCATCGAGAGCCGCAAAGGCGCGCCCGGTC
GAACGGCCCTGGAACGGCTGTTGCGCGAGGGTGACATCGAGACCGCCGCGGTCACACCGCAGCAGGCGGACCTCGCTGCT
GATGCGGCCCAAAGGTTCGGCTCGGGCCGGCACTCGGCCGCACTGACCCTGGGCGATTGCTTTGCCTACGCCCTGGCCCA
GATCGTCGGCCTGCCCCTGCTGTTCAGGGACGAGCGGTTCCGGCACACGGATGTCACCGCCGCCCTGCACGGCGGATAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9057.40 Da        Isoelectric Point: 11.4948

>AT105143 WP_114910986.1 NZ_CP029176:526463-526720 [Acidibrevibacterium fodinaquatile]
MALSLKDPETDHLARALAALAGETLTEAIRRALAERLARERIRRGHQGGLAGRIREIGEHCAALPDVASPATGAPPGRGA
ARMWR

Download         Length: 258 bp

>AT105143 NZ_CP029176:526463-526720 [Acidibrevibacterium fodinaquatile]
ATGGCCCTTAGCCTGAAGGACCCTGAGACCGACCACCTCGCCCGGGCGCTGGCAGCGCTGGCCGGGGAGACGCTCACGGA
GGCGATCCGTAGGGCGTTGGCCGAGCGGCTGGCGCGCGAGCGGATCCGACGGGGCCATCAGGGCGGCCTCGCTGGCCGGA
TCCGCGAGATCGGCGAGCACTGTGCCGCGCTGCCCGACGTGGCCTCACCTGCGACGGGTGCACCGCCTGGACGTGGTGCC
GCAAGGATGTGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References