Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2231873..2232387 Replicon chromosome
Accession NZ_CP029172
Organism Staphylococcus aureus strain PTDrAP2

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag DD562_RS11445 Protein ID WP_000581792.1
Coordinates 2231873..2232082 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag DD562_RS11450 Protein ID WP_000138932.1
Coordinates 2232094..2232387 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD562_RS11425 2227384..2228739 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
DD562_RS11430 2228754..2229824 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
DD562_RS11435 2230142..2231344 + 1203 WP_001109939.1 rod shape-determining protein RodA -
DD562_RS11440 2231608..2231745 - 138 WP_000828354.1 hypothetical protein -
DD562_RS11445 2231873..2232082 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
DD562_RS11450 2232094..2232387 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
DD562_RS11455 2232553..2234037 + 1485 WP_000571550.1 cardiolipin synthase -
DD562_RS11460 2234065..2234712 + 648 WP_001187614.1 HD domain-containing protein -
DD562_RS11465 2234992..2235312 + 321 WP_001825748.1 hypothetical protein -
DD562_RS11470 2235309..2236624 - 1316 Protein_2087 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T105138 WP_000581792.1 NZ_CP029172:c2232082-2231873 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T105138 NZ_CP029172:c2232082-2231873 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT105138 WP_000138932.1 NZ_CP029172:c2232387-2232094 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT105138 NZ_CP029172:c2232387-2232094 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References