Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | TsdAT/- |
Location | 2231873..2232387 | Replicon | chromosome |
Accession | NZ_CP029172 | ||
Organism | Staphylococcus aureus strain PTDrAP2 |
Toxin (Protein)
Gene name | TsdT | Uniprot ID | T1YA99 |
Locus tag | DD562_RS11445 | Protein ID | WP_000581792.1 |
Coordinates | 2231873..2232082 (-) | Length | 70 a.a. |
Antitoxin (Protein)
Gene name | TsdA | Uniprot ID | W8UW13 |
Locus tag | DD562_RS11450 | Protein ID | WP_000138932.1 |
Coordinates | 2232094..2232387 (-) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
DD562_RS11425 | 2227384..2228739 | - | 1356 | WP_000611457.1 | UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase | - |
DD562_RS11430 | 2228754..2229824 | - | 1071 | WP_000159641.1 | D-alanine--D-alanine ligase | - |
DD562_RS11435 | 2230142..2231344 | + | 1203 | WP_001109939.1 | rod shape-determining protein RodA | - |
DD562_RS11440 | 2231608..2231745 | - | 138 | WP_000828354.1 | hypothetical protein | - |
DD562_RS11445 | 2231873..2232082 | - | 210 | WP_000581792.1 | heavy-metal-associated domain-containing protein | Toxin |
DD562_RS11450 | 2232094..2232387 | - | 294 | WP_000138932.1 | copper-sensing transcriptional repressor CsoR | Antitoxin |
DD562_RS11455 | 2232553..2234037 | + | 1485 | WP_000571550.1 | cardiolipin synthase | - |
DD562_RS11460 | 2234065..2234712 | + | 648 | WP_001187614.1 | HD domain-containing protein | - |
DD562_RS11465 | 2234992..2235312 | + | 321 | WP_001825748.1 | hypothetical protein | - |
DD562_RS11470 | 2235309..2236624 | - | 1316 | Protein_2087 | ISL3 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 70 a.a. Molecular weight: 7843.77 Da Isoelectric Point: 4.1008
>T105138 WP_000581792.1 NZ_CP029172:c2232082-2231873 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF
Download Length: 210 bp
>T105138 NZ_CP029172:c2232082-2231873 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATTGATGGTCAAGTAACGGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATTTATGATGAAGGATACAAAATTGTATTTTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 11197.82 Da Isoelectric Point: 6.2243
>AT105138 WP_000138932.1 NZ_CP029172:c2232387-2232094 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD
Download Length: 294 bp
>AT105138 NZ_CP029172:c2232387-2232094 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGAGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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