Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 989716..990192 Replicon chromosome
Accession NZ_CP029172
Organism Staphylococcus aureus strain PTDrAP2

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag DD562_RS05100 Protein ID WP_000052076.1
Coordinates 989716..989904 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag DD562_RS05105 Protein ID WP_001059690.1
Coordinates 989932..990192 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD562_RS05065 985291..985527 - 237 WP_001159903.1 hypothetical protein -
DD562_RS05070 985772..986227 + 456 WP_016187138.1 hypothetical protein -
DD562_RS05075 986568..987254 + 687 WP_001574556.1 thermonuclease family protein -
DD562_RS05080 987611..987811 + 201 WP_001059082.1 cold-shock protein -
DD562_RS05085 988308..988526 - 219 WP_000005881.1 hypothetical protein -
DD562_RS05090 988587..988871 - 285 WP_001004403.1 hypothetical protein -
DD562_RS05095 988959..989528 - 570 WP_001106655.1 hypothetical protein -
DD562_RS05100 989716..989904 - 189 WP_000052076.1 hypothetical protein Toxin
DD562_RS05105 989932..990192 - 261 WP_001059690.1 hypothetical protein Antitoxin
DD562_RS05110 990534..990737 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
DD562_RS05115 990734..990970 - 237 WP_000368687.1 hypothetical protein -
DD562_RS05120 991195..991776 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
DD562_RS05125 991849..992466 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
DD562_RS05130 992615..993109 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
DD562_RS05135 993508..993930 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
DD562_RS05140 994078..994794 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T105134 WP_000052076.1 NZ_CP029172:c989904-989716 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T105134 NZ_CP029172:c989904-989716 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT105134 WP_001059690.1 NZ_CP029172:c990192-989932 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT105134 NZ_CP029172:c990192-989932 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References