Detailed information of TA system TA105131

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /HTH_19(antitoxin)
• Location: 417033..417821
• Replicon: chromosome
• Accession: NZ_CP029172
• Organism: Staphylococcus aureus strain PTDrAP2

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: DD562_RS02050
• Protein ID: WP_109028188.1
• Coordinates: 417033..417494 (-)
• Length: 154 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A0E7YIA0
• Locus tag: DD562_RS02055
• Protein ID: WP_000333630.1
• Coordinates: 417507..417821 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD562_RS02030	412085..414019	+	1935	Protein_362	YSIRK domain-containing triacylglycerol lipase Lip2/Geh	-
DD562_RS02035	414113..415318	-	1206	WP_000264745.1	site-specific integrase	-
DD562_RS02040	415444..416058	+	615	WP_000191466.1	hypothetical protein	-
DD562_RS02045	416431..417015	-	585	WP_000825948.1	hypothetical protein	-
DD562_RS02050	417033..417494	-	462	WP_109028188.1	toxin	Toxin
DD562_RS02055	417507..417821	-	315	WP_000333630.1	helix-turn-helix domain-containing protein	Antitoxin
DD562_RS02060	417973..418209	+	237	WP_001121027.1	helix-turn-helix domain-containing protein	-
DD562_RS02065	418223..418999	+	777	WP_001148544.1	Rha family transcriptional regulator	-
DD562_RS14950	419028..419177	+	150	WP_000771849.1	hypothetical protein	-
DD562_RS02070	419218..419430	-	213	WP_000362644.1	hypothetical protein	-
DD562_RS02075	419500..419697	+	198	WP_109028189.1	hypothetical protein	-
DD562_RS02080	419684..420064	-	381	WP_000773060.1	DUF2513 domain-containing protein	-
DD562_RS02085	420131..420376	+	246	WP_109028190.1	DUF2829 domain-containing protein	-
DD562_RS02090	420435..420761	+	327	WP_001588858.1	hypothetical protein	-
DD562_RS02095	420776..420919	+	144	WP_000939502.1	hypothetical protein	-
DD562_RS02100	420909..421118	-	210	WP_000642492.1	hypothetical protein	-
DD562_RS02105	421174..421389	+	216	WP_001097552.1	hypothetical protein	-
DD562_RS02110	421414..421677	+	264	WP_001124160.1	helix-turn-helix domain-containing protein	-
DD562_RS02115	421690..421851	+	162	WP_001285954.1	DUF1270 domain-containing protein	-
DD562_RS02120	421930..422253	+	324	WP_000174994.1	hypothetical protein	-
DD562_RS02125	422268..422630	+	363	WP_031808061.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	414113..459693	45580

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (4-62)

Sequences

Toxin

Protein

• Length: 154 a.a.
• Molecular weight: 18044.48 Da
• Isoelectric Point: 4.7834

>T105131 WP_109028188.1 NZ_CP029172:c417494-417033 [Staphylococcus aureus]
MGLYEETLIQHDYIVIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Nucleotide

• Length: 462 bp

>T105131 NZ_CP029172:c417494-417033 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGTAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 12063.56 Da
• Isoelectric Point: 6.4736

>AT105131 WP_000333630.1 NZ_CP029172:c417821-417507 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Nucleotide

• Length: 315 bp

>AT105131 NZ_CP029172:c417821-417507 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0E7YIA0