Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1635560..1636348 Replicon chromosome
Accession NZ_CP029166
Organism Staphylococcus aureus strain SVH7513

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag DD555_RS08365 Protein ID WP_000525004.1
Coordinates 1635887..1636348 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag DD555_RS08360 Protein ID WP_000333630.1
Coordinates 1635560..1635874 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DD555_RS08300 1630702..1631868 - 1167 WP_084986307.1 DUF2800 domain-containing protein -
DD555_RS08305 1631865..1632227 - 363 WP_084986306.1 hypothetical protein -
DD555_RS08310 1632242..1632565 - 324 WP_000175001.1 hypothetical protein -
DD555_RS08315 1632644..1632805 - 162 WP_001285954.1 DUF1270 domain-containing protein -
DD555_RS08320 1632818..1633081 - 264 WP_001124160.1 helix-turn-helix domain-containing protein -
DD555_RS08325 1633106..1633321 - 216 WP_001097552.1 hypothetical protein -
DD555_RS08330 1633376..1633741 + 366 WP_001128433.1 hypothetical protein -
DD555_RS08335 1633710..1633955 - 246 WP_001025401.1 DUF2829 domain-containing protein -
DD555_RS08340 1634011..1634220 + 210 WP_000642492.1 hypothetical protein -
DD555_RS08345 1634210..1634353 - 144 WP_000939498.1 hypothetical protein -
DD555_RS08350 1634382..1635158 - 777 WP_001148544.1 Rha family transcriptional regulator -
DD555_RS08355 1635172..1635408 - 237 WP_001121027.1 helix-turn-helix domain-containing protein -
DD555_RS08360 1635560..1635874 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
DD555_RS08365 1635887..1636348 + 462 WP_000525004.1 hypothetical protein Toxin
DD555_RS08370 1636366..1636950 + 585 WP_000825948.1 hypothetical protein -
DD555_RS08375 1637180..1637326 + 147 WP_001013104.1 hypothetical protein -
DD555_RS08380 1637323..1637937 - 615 WP_000191459.1 hypothetical protein -
DD555_RS08385 1638063..1639268 + 1206 WP_020444721.1 site-specific integrase -
DD555_RS08390 1639311..1641338 - 2028 WP_084927664.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1593686..1652024 58338


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T105113 WP_000525004.1 NZ_CP029166:1635887-1636348 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T105113 NZ_CP029166:1635887-1636348 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTGGA
TGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGCTTATCAGATAGAGAAAAGGCAGGAATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGG
CGACACGGCTTTATCTCAGCAGTCCCGTTACGCGAAATTGTGGAAGCTTACAATTATGGTGTACGTAACTTGTATGAGTT
GTCTGAGTATCTGCAATTGAGTGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGGACTC
ACTACGGCGAATACTCAATTACATTTGAGCCATTGAGAGTTTTTAAATATAAAGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT105113 WP_000333630.1 NZ_CP029166:1635560-1635874 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT105113 NZ_CP029166:1635560-1635874 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAGCGTTATGAAAGCGGAAATATCAAAAATTTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCATATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCACCTT
GAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References