Detailed information of TA system TA105109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 940280..940812
• Replicon: chromosome
• Accession: NZ_CP029166
• Organism: Staphylococcus aureus strain SVH7513

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: Q93CD4
• Locus tag: DD555_RS04865
• Protein ID: WP_001103942.1
• Coordinates: 940492..940812 (+)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: DD555_RS04860
• Protein ID: WP_001058486.1
• Coordinates: 940280..940489 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD555_RS04815	935299..936519	-	1221	WP_000266157.1	site-specific integrase	-
DD555_RS04820	936608..937336	-	729	WP_000733775.1	staphylococcal enterotoxin type K	-
DD555_RS04825	937360..938088	-	729	WP_001033316.1	staphylococcal enterotoxin type Q	-
DD555_RS04830	938158..938589	-	432	WP_001228759.1	hypothetical protein	-
DD555_RS04835	938606..939064	-	459	WP_000281657.1	ImmA/IrrE family metallo-endopeptidase	-
DD555_RS04840	939076..939408	-	333	WP_001260004.1	helix-turn-helix transcriptional regulator	-
DD555_RS04845	939601..939864	+	264	WP_000243850.1	helix-turn-helix domain-containing protein	-
DD555_RS04850	939857..940129	+	273	WP_000091731.1	helix-turn-helix domain-containing protein	-
DD555_RS04855	940141..940287	+	147	WP_000784875.1	hypothetical protein	-
DD555_RS04860	940280..940489	+	210	WP_001058486.1	hypothetical protein	Antitoxin
DD555_RS04865	940492..940812	+	321	WP_001103942.1	DUF1474 family protein	Toxin
DD555_RS04870	940876..941745	+	870	WP_001002732.1	primase alpha helix C-terminal domain-containing protein	-
DD555_RS04875	941762..943219	+	1458	WP_000390455.1	virulence-associated E family protein	-
DD555_RS04880	943520..943882	+	363	WP_001039168.1	hypothetical protein	-
DD555_RS04885	943884..944168	+	285	WP_000998181.1	hypothetical protein	-
DD555_RS04890	944165..944806	+	642	WP_001019764.1	hypothetical protein	-
DD555_RS04895	945323..945664	+	342	WP_001190615.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	selk / selq / seb	917351..950614	33263

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12694.22 Da
• Isoelectric Point: 4.7419

>T105109 WP_001103942.1 NZ_CP029166:940492-940812 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFSELIQKF
HEIEKASSENFDEESDDAKNSIKVAE

Nucleotide

• Length: 321 bp

>T105109 NZ_CP029166:940492-940812 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8252.31 Da
• Isoelectric Point: 4.3718

>AT105109 WP_001058486.1 NZ_CP029166:940280-940489 [Staphylococcus aureus]
MNNEQKEVIEHLVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT105109 NZ_CP029166:940280-940489 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: Q93CD4