Detailed information of TA system TA105107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 428301..428830
• Replicon: chromosome
• Accession: NZ_CP029166
• Organism: Staphylococcus aureus strain SVH7513

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: DD555_RS02090
• Protein ID: WP_084938006.1
• Coordinates: 428513..428830 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IY59
• Locus tag: DD555_RS02085
• Protein ID: WP_001058494.1
• Coordinates: 428301..428510 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DD555_RS02050	423445..424242	-	798	WP_000119675.1	type II toxin-antitoxin system PemK/MazF family toxin	-
DD555_RS02055	424266..425483	-	1218	WP_084938017.1	site-specific integrase	-
DD555_RS02060	425497..426885	-	1389	WP_001661453.1	SAP domain-containing protein	-
DD555_RS02065	426912..427484	-	573	WP_001661454.1	helix-turn-helix domain-containing protein	-
DD555_RS02070	427656..427877	+	222	WP_000560872.1	helix-turn-helix domain-containing protein	-
DD555_RS02075	427878..428150	+	273	WP_000124597.1	helix-turn-helix domain-containing protein	-
DD555_RS02080	428162..428308	+	147	WP_000784893.1	hypothetical protein	-
DD555_RS02085	428301..428510	+	210	WP_001058494.1	hypothetical protein	Antitoxin
DD555_RS02090	428513..428830	+	318	WP_084938006.1	DUF1474 family protein	Toxin
DD555_RS02095	428894..429763	+	870	WP_070064471.1	primase alpha helix C-terminal domain-containing protein	-
DD555_RS02100	429777..431486	+	1710	WP_070064470.1	DUF927 domain-containing protein	-
DD555_RS02105	431816..432196	+	381	WP_070064469.1	hypothetical protein	-
DD555_RS02110	432193..432834	+	642	WP_001047694.1	hypothetical protein	-
DD555_RS02115	433181..433522	+	342	WP_001190609.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	tet(M)	-	386520..491253	104733

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12576.22 Da
• Isoelectric Point: 5.2529

>T105107 WP_084938006.1 NZ_CP029166:428513-428830 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVKDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEESDDAQKLKITE

Nucleotide

• Length: 318 bp

>T105107 NZ_CP029166:428513-428830 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTAAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCGGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCATCATCTGAGAACTTTGGCGAGGAATCAGATGACGCACAAAAATTAAAAATCACAGAGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8268.31 Da
• Isoelectric Point: 4.3718

>AT105107 WP_001058494.1 NZ_CP029166:428301-428510 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT105107 NZ_CP029166:428301-428510 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATAGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Antitoxin

• AlphaFold DB: X5IY59