105089

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2280609..2281234 Replicon chromosome
Accession NZ_CP029164
Organism Escherichia coli strain 104

Toxin (Protein)


Gene name vapC Uniprot ID U9YZ02
Locus tag DDV95_RS11700 Protein ID WP_000911329.1
Coordinates 2280836..2281234 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag DDV95_RS11695 Protein ID WP_000450524.1
Coordinates 2280609..2280836 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDV95_RS11670 2276409..2276879 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
DDV95_RS11675 2276879..2277451 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
DDV95_RS11680 2277597..2278475 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
DDV95_RS11685 2278492..2279526 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
DDV95_RS11690 2279739..2280452 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
DDV95_RS11695 2280609..2280836 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
DDV95_RS11700 2280836..2281234 + 399 WP_000911329.1 tRNA(fMet)-specific endonuclease VapC Toxin
DDV95_RS11705 2281381..2282244 + 864 WP_001267498.1 neutral zinc metallopeptidase -
DDV95_RS11710 2282259..2284274 + 2016 WP_000829310.1 tRNA cytosine(34) acetyltransferase TmcA -
DDV95_RS11715 2284348..2285046 + 699 WP_000679819.1 esterase -
DDV95_RS11720 2285127..2285327 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14924.23 Da        Isoelectric Point: 8.5325

>T105089 WP_000911329.1 NZ_CP029164:2280836-2281234 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLEVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

>T105089 NZ_CP029164:2280836-2281234 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAACATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTAACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT105089 WP_000450524.1 NZ_CP029164:2280609-2280836 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp

>AT105089 NZ_CP029164:2280609-2280836 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XW84

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References