105088

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1839278..1839932 Replicon chromosome
Accession NZ_CP029164
Organism Escherichia coli strain 104

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag DDV95_RS09645 Protein ID WP_000244781.1
Coordinates 1839525..1839932 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag DDV95_RS09640 Protein ID WP_000354046.1
Coordinates 1839278..1839544 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDV95_RS09615 1835356..1836789 - 1434 WP_001389468.1 6-phospho-beta-glucosidase BglA -
DDV95_RS09620 1836834..1837145 + 312 WP_001182953.1 N(4)-acetylcytidine aminohydrolase -
DDV95_RS09625 1837309..1837968 + 660 WP_000250269.1 hemolysin III family protein -
DDV95_RS09630 1838045..1839025 - 981 WP_000886050.1 tRNA-modifying protein YgfZ -
DDV95_RS09640 1839278..1839544 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
DDV95_RS09645 1839525..1839932 + 408 WP_000244781.1 protein YgfX Toxin
DDV95_RS09650 1839972..1840493 - 522 WP_001055874.1 flavodoxin FldB -
DDV95_RS09655 1840605..1841501 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
DDV95_RS09660 1841526..1842236 + 711 WP_000715230.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DDV95_RS09665 1842242..1843975 + 1734 WP_000813191.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T105088 WP_000244781.1 NZ_CP029164:1839525-1839932 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T105088 NZ_CP029164:1839525-1839932 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT105088 WP_000354046.1 NZ_CP029164:1839278-1839544 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT105088 NZ_CP029164:1839278-1839544 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCAGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References