Detailed information of TA system TA105077

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 62066..62880
• Replicon: chromosome
• Accession: NZ_CP029164
• Organism: Escherichia coli strain 104

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: S1PA82
• Locus tag: DDV95_RS00315
• Protein ID: WP_001054376.1
• Coordinates: 62066..62323 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: A0A8E0IVE5
• Locus tag: DDV95_RS00320
• Protein ID: WP_001350781.1
• Coordinates: 62335..62880 (+)
• Length: 182 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DDV95_RS00285	57354..58460	+	1107	WP_001309184.1	N-acetylneuraminate epimerase	-
DDV95_RS00290	58525..59505	+	981	WP_000991438.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
DDV95_RS00295	60088..61328	-	1241	Protein_51	helicase YjhR	-
DDV95_RS00305	61444..61689	+	246	Protein_52	GNAT family N-acetyltransferase	-
DDV95_RS00315	62066..62323	+	258	WP_001054376.1	hypothetical protein	Toxin
DDV95_RS00320	62335..62880	+	546	WP_001350781.1	N-acetyltransferase	Antitoxin
DDV95_RS00325	62936..63682	+	747	WP_000354251.1	class I SAM-dependent methyltransferase	-
DDV95_RS00330	63851..64069	+	219	Protein_56	hypothetical protein	-
DDV95_RS25905	64107..64223	+	117	Protein_57	VOC family protein	-
DDV95_RS00335	64468..65589	+	1122	WP_000010832.1	M42 family metallopeptidase	-
DDV95_RS00340	65586..65864	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
DDV95_RS00345	65876..67189	+	1314	WP_000460843.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimI / fimA / fimE / fimB	51851..71104	19253

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (18-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9734.29 Da
• Isoelectric Point: 11.0090

>T105077 WP_001054376.1 NZ_CP029164:62066-62323 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Nucleotide

• Length: 258 bp

>T105077 NZ_CP029164:62066-62323 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACATACCTTACACGTTCTCGCTAAAGGTAGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGCCAGCCCTATCGAATCAACACCACCGAGCTGAATAAAGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 182 a.a.
• Molecular weight: 19974.91 Da
• Isoelectric Point: 6.3277

>AT105077 WP_001350781.1 NZ_CP029164:62335-62880 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFGKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAFIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Nucleotide

• Length: 546 bp

>AT105077 NZ_CP029164:62335-62880 [Escherichia coli]
ATGACAGTACACCACTTCACTTTTCATATCACAGATAAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCGGCAAAGAAGCCGATTTAGTGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCCGCGTTATCGCTGCTAGCCC
GGTATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGAGAAATGGATTCACCGTTGATGCAC
ATCCTCGCTCCCCTGGCTTTCATACCGGAATACCAAGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAATCACTCACCGCT
CAGCCCATGACCCTGACCGGCCACATCCGGTGCGCAGACCCTGATGAAACCGGAGCACTGACGTGA

Structures

Toxin

• AlphaFold DB: S1PA82