Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 2842786..2843311 Replicon chromosome
Accession NZ_CP029159
Organism Streptomyces tsukubensis NRRL18488

Toxin (Protein)


Gene name relE Uniprot ID I2N5J6
Locus tag STSU_RS11400 Protein ID WP_006346847.1
Coordinates 2843048..2843311 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7G3UBC1
Locus tag STSU_RS11395 Protein ID WP_030744248.1
Coordinates 2842786..2843055 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STSU_RS11375 2837891..2838643 - 753 WP_006346841.1 GntR family transcriptional regulator -
STSU_RS11380 2838938..2840281 + 1344 WP_040914462.1 glycoside hydrolase family 18 protein -
STSU_RS11385 2840660..2842105 - 1446 WP_130584856.1 DUF4190 domain-containing protein -
STSU_RS11390 2842346..2842696 + 351 WP_006346845.1 DUF4326 domain-containing protein -
STSU_RS11395 2842786..2843055 + 270 WP_030744248.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
STSU_RS11400 2843048..2843311 + 264 WP_006346847.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
STSU_RS11405 2843446..2844534 - 1089 WP_006346848.1 redox-regulated ATPase YchF -
STSU_RS11410 2844914..2845513 + 600 WP_006346849.1 hypothetical protein -
STSU_RS11415 2845559..2846314 - 756 WP_040914468.1 ROK family protein -
STSU_RS11420 2846345..2847349 - 1005 WP_040914471.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(10-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10040.52 Da        Isoelectric Point: 7.1641

>T105075 WP_006346847.1 NZ_CP029159:2843048-2843311 [Streptomyces tsukubensis NRRL18488]
VSEYRTVFCPEAQAELRKIPRDMALRILAKLTELEADPLGFSTTALVSQPDRRRLRMGDYRVVYTIDNGELVVWFVHVGH
RSTVYDT

Download         Length: 264 bp

>T105075 NZ_CP029159:2843048-2843311 [Streptomyces tsukubensis NRRL18488]
GTGAGTGAGTACCGAACCGTCTTCTGCCCCGAAGCGCAGGCCGAACTCCGGAAGATCCCCCGCGATATGGCGCTGCGCAT
CCTGGCCAAGCTGACCGAACTGGAGGCCGATCCACTCGGCTTCAGCACCACCGCGCTCGTGTCCCAGCCGGACCGCCGAC
GCCTGCGGATGGGCGACTACCGCGTCGTCTACACGATCGACAATGGAGAGTTGGTGGTTTGGTTCGTTCATGTGGGACAT
CGGTCCACCGTCTACGACACCTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10258.73 Da        Isoelectric Point: 4.7473

>AT105075 WP_030744248.1 NZ_CP029159:2842786-2843055 [Streptomyces tsukubensis NRRL18488]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRIIDERMANPAPGIPIEDI
MRETLARGE

Download         Length: 270 bp

>AT105075 NZ_CP029159:2842786-2843055 [Streptomyces tsukubensis NRRL18488]
ATGACACAGCCGCTGCCCATAGAGTCCATCCGTGACGTGCGTGCACATTTGGCGGAGGTCGTGGAGCGCGCGGACCGGGA
CGATGTGCCCACCGTGATCACCCGACGCGGCAAGCAGGTCGCCGCCGTCGTCTCCATCGAGGTGCTGCGCAAATACCAGG
AGTGGGAAGAGCGCGAGATCAACCGGATCATCGACGAGCGCATGGCCAACCCGGCTCCCGGCATCCCGATCGAGGACATC
ATGAGGGAGACGCTGGCCCGCGGTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2N5J6

Antitoxin

Source ID Structure
AlphaFold DB A0A7G3UBC1

References