Detailed information of TA system TA105055

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2025969..2027518
• Replicon: chromosome
• Accession: NZ_CP029150
• Organism: Glaesserella parasuis strain GZ20170512

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: C3363_RS10070
• Protein ID: WP_159179997.1
• Coordinates: 2025969..2027285 (-)
• Length: 439 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: U4SAZ6
• Locus tag: C3363_RS10075
• Protein ID: WP_010786623.1
• Coordinates: 2027279..2027518 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3363_RS10055	2022923..2023795	+	873	WP_159179996.1	LysR family transcriptional regulator	-
C3363_RS10060	2023856..2024470	-	615	WP_010787298.1	DsbA family protein	-
C3363_RS11490	2024579..2024812	+	234	WP_201288379.1	GntR family transcriptional regulator	-
C3363_RS10065	2024823..2025965	+	1143	WP_201288380.1	PLP-dependent aminotransferase family protein	-
C3363_RS10070	2025969..2027285	-	1317	WP_159179997.1	type II toxin-antitoxin system HipA family toxin	Toxin
C3363_RS10075	2027279..2027518	-	240	WP_010786623.1	helix-turn-helix domain-containing protein	Antitoxin
C3363_RS10080	2027665..2028492	-	828	WP_021118603.1	alpha/beta hydrolase	-
C3363_RS10085	2028623..2030068	+	1446	WP_159179998.1	metalloprotease TldD	-
C3363_RS10090	2030324..2030734	+	411	WP_010786620.1	preprotein translocase subunit SecE	-
C3363_RS10095	2030736..2031314	+	579	WP_005713298.1	transcription termination/antitermination protein NusG	-
C3363_RS10100	2031440..2031694	-	255	WP_005713300.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-104)

Antitoxin

• HigA2-like, helix-turn-helix domain (12-66)

Sequences

Toxin

Protein

• Length: 439 a.a.
• Molecular weight: 50001.28 Da
• Isoelectric Point: 7.6047

>T105055 WP_159179997.1 NZ_CP029150:c2027285-2025969 [Glaesserella parasuis]
MVMRLRVLMNGEMVGYFDRTLSGSHHFTYAESWLNSPLARPISLSMPLQRATYQGKEVINFFDNLLPDNPQIRARIATRF
NAETQQPFDLLAKIGRDAAGAITLLGEDEQIPNHRIIQATELNESEMTKILQSYQYNAPLGMIDNNQDFRISIAGAQEKT
AMLWHNGKWKLPHGLTPTTHIFKLPMGEIRTPKHLLDLSKSVDNELVCLRLFSAFNIPSANVELLEMNDIRALAVERFDR
RLSQDGSYFLRLPYEDFCQAFGLSPTQKYESDGGVGIGDMMNKLLYSSNPNDRRQFMQTQFLFWLLAAIDGHAKNFSLAI
EKQGRYHLSPVYDVLSAYPMLGGKGWHHSELQMAMSLRSTQKGKKWHWSKIYAEHFYATAKFVGFSSSDMKQVIEQICDT
VQETIDSVATTLPKQIDENVRDQIFTGIMKQVQKVSMK

Nucleotide

• Length: 1317 bp

>T105055 NZ_CP029150:c2027285-2025969 [Glaesserella parasuis]
ATGGTAATGCGATTACGAGTATTAATGAATGGCGAAATGGTTGGGTATTTTGACCGCACTTTATCGGGTTCCCACCATTT
TACCTATGCTGAAAGTTGGCTAAATTCCCCATTAGCTCGCCCGATTTCCCTTTCTATGCCCTTGCAAAGAGCAACATATC
AAGGCAAAGAAGTGATTAATTTCTTTGATAATTTACTGCCCGATAATCCTCAAATTCGAGCAAGAATTGCGACAAGATTT
AATGCTGAAACACAACAACCTTTTGACTTACTTGCTAAAATTGGTCGCGATGCTGCGGGTGCTATTACTCTTTTAGGGGA
AGATGAACAAATTCCTAATCATCGAATAATTCAAGCCACAGAATTAAACGAGAGTGAAATGACGAAAATTCTACAAAGTT
ATCAATACAATGCCCCGCTTGGTATGATTGATAATAATCAGGACTTCAGAATTTCTATTGCTGGTGCACAAGAAAAAACA
GCTATGCTTTGGCATAACGGCAAATGGAAATTACCACACGGATTGACCCCGACAACGCATATTTTCAAATTGCCTATGGG
AGAAATTCGTACCCCTAAACACCTGCTTGATCTGTCAAAAAGTGTAGATAACGAACTCGTCTGTTTGAGATTATTTTCTG
CTTTCAATATCCCTTCCGCAAACGTTGAATTATTGGAAATGAACGATATACGGGCATTAGCTGTTGAACGTTTTGATCGC
CGTCTTAGTCAAGATGGCAGTTATTTTTTACGTTTACCTTACGAAGATTTCTGTCAGGCATTCGGCTTATCGCCAACGCA
AAAATATGAAAGCGATGGTGGAGTTGGTATTGGGGATATGATGAATAAGTTGCTCTACTCCAGTAATCCCAACGATCGCC
GTCAATTTATGCAAACTCAATTTCTGTTTTGGCTACTGGCTGCCATTGATGGACATGCTAAAAACTTTTCTCTCGCCATT
GAAAAACAAGGGCGTTATCACTTATCCCCAGTGTATGACGTACTTTCTGCTTATCCAATGTTAGGCGGAAAAGGTTGGCA
TCACAGTGAATTACAAATGGCAATGAGCTTGCGTAGCACACAAAAAGGAAAAAAATGGCATTGGAGTAAAATTTATGCTG
AACATTTCTATGCCACAGCTAAGTTTGTCGGATTTAGCTCAAGTGATATGAAACAAGTGATAGAGCAAATTTGCGATACA
GTGCAAGAAACCATTGATAGCGTAGCAACAACACTACCCAAACAGATAGATGAAAATGTACGGGATCAAATATTCACGGG
CATAATGAAACAGGTGCAAAAAGTTTCTATGAAGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9059.47 Da
• Isoelectric Point: 9.7684

>AT105055 WP_010786623.1 NZ_CP029150:c2027518-2027279 [Glaesserella parasuis]
MLITTPDMLGNSLRDIRKQKKLSQMQIANQVALRQATISTFEKKTDKATIETLFKLLSGLGYELHIQPRPEKTEGNDEW

Nucleotide

• Length: 240 bp

>AT105055 NZ_CP029150:c2027518-2027279 [Glaesserella parasuis]
ATGTTAATCACGACACCAGATATGCTTGGAAATAGCCTACGCGATATTCGTAAGCAAAAAAAGCTTTCTCAAATGCAAAT
AGCAAATCAAGTAGCTTTAAGACAAGCCACGATTTCCACCTTTGAGAAAAAAACCGATAAAGCCACTATTGAAACATTAT
TTAAGTTACTTTCAGGTTTAGGCTATGAACTACATATCCAACCTCGTCCTGAAAAAACAGAGGGGAATGATGAATGGTAA

Structures

Antitoxin

• AlphaFold DB: U4SAZ6