Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 1650045..1650584 Replicon chromosome
Accession NZ_CP029150
Organism Glaesserella parasuis strain GZ20170512

Toxin (Protein)


Gene name relE Uniprot ID A0A6I5WQI8
Locus tag C3363_RS08060 Protein ID WP_005714578.1
Coordinates 1650045..1650314 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B8F4J9
Locus tag C3363_RS08065 Protein ID WP_005714576.1
Coordinates 1650318..1650584 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3363_RS08040 1645696..1646028 - 333 WP_020997028.1 phage tail protein -
C3363_RS08045 1646073..1647272 - 1200 Protein_1560 phage tail tape measure protein -
C3363_RS08050 1648025..1649632 - 1608 WP_159179967.1 tape measure protein -
C3363_RS08055 1649695..1649961 - 267 WP_075592536.1 hypothetical protein -
C3363_RS08060 1650045..1650314 - 270 WP_005714578.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
C3363_RS08065 1650318..1650584 - 267 WP_005714576.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
C3363_RS08070 1650653..1650880 - 228 WP_005714573.1 DUF4035 domain-containing protein -
C3363_RS08075 1650925..1651326 - 402 WP_005714571.1 hypothetical protein -
C3363_RS08080 1651400..1652065 - 666 WP_075592537.1 hypothetical protein -
C3363_RS08085 1652068..1652487 - 420 WP_005714567.1 phage tail protein -
C3363_RS08090 1652487..1653020 - 534 WP_075592538.1 phage tail protein -
C3363_RS08095 1653024..1653329 - 306 WP_010786319.1 bacteriophage tail protein -
C3363_RS08100 1653322..1653648 - 327 WP_005714561.1 DUF2190 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1636348..1663786 27438


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-80)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10310.03 Da        Isoelectric Point: 6.8591

>T105053 WP_005714578.1 NZ_CP029150:c1650314-1650045 [Glaesserella parasuis]
MLQLSPTNAYKRDFKKIASELMSSAEYIEVMYCLMHQLPLAEKYKDHPLQGELQGFRDCHIKPDLVLIYAVENNLLRLVR
LGSHSELFG

Download         Length: 270 bp

>T105053 NZ_CP029150:c1650314-1650045 [Glaesserella parasuis]
ATGTTACAACTTTCTCCAACAAATGCTTATAAAAGAGATTTTAAAAAGATTGCTTCTGAGTTAATGTCTAGTGCTGAATA
TATAGAAGTGATGTATTGTTTAATGCATCAGTTACCTTTGGCGGAGAAATATAAAGATCACCCATTACAAGGAGAATTAC
AAGGTTTTAGAGATTGCCATATCAAACCTGATCTTGTTTTGATTTATGCGGTTGAAAATAATTTACTTCGCTTGGTACGT
TTAGGATCACATTCCGAATTATTTGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9945.38 Da        Isoelectric Point: 5.0366

>AT105053 WP_005714576.1 NZ_CP029150:c1650584-1650318 [Glaesserella parasuis]
MATINDAFSFRTNTEVKNTAFEVIKSYGMTPSQVFNMLLTEIAYTKTIPLSLNYQPNLETKLAMQEAKSGKNEVYESLEA
FHKAMLAE

Download         Length: 267 bp

>AT105053 NZ_CP029150:c1650584-1650318 [Glaesserella parasuis]
ATGGCGACCATTAATGATGCTTTCAGTTTTAGAACAAACACAGAAGTTAAAAATACGGCTTTTGAAGTGATAAAAAGTTA
TGGAATGACTCCATCACAAGTGTTTAATATGCTTCTCACTGAAATTGCATATACTAAAACAATTCCGTTAAGTTTGAATT
ATCAACCAAACCTTGAGACTAAGTTGGCAATGCAGGAAGCTAAATCAGGTAAGAATGAGGTATATGAATCTTTGGAAGCG
TTTCATAAAGCAATGTTAGCGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6I5WQI8

Antitoxin

Source ID Structure
AlphaFold DB B8F4J9

References