Detailed information of TA system TA105052

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 1416559..1417336
• Replicon: chromosome
• Accession: NZ_CP029150
• Organism: Glaesserella parasuis strain GZ20170512

Toxin (Protein)

• Gene name: TacT3
• Uniprot ID: -
• Locus tag: C3363_RS06895
• Protein ID: WP_159179937.1
• Coordinates: 1416559..1417059 (-)
• Length: 167 a.a.

Antitoxin (Protein)

• Gene name: TacA3
• Uniprot ID: U4SPD7
• Locus tag: C3363_RS06900
• Protein ID: WP_005710653.1
• Coordinates: 1417049..1417336 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
C3363_RS06860	1411685..1411840	-	156	WP_005710668.1	YoaH family protein	-
C3363_RS06865	1411858..1412586	-	729	WP_010786651.1	tRNA pseudouridine(65) synthase TruC	-
C3363_RS06870	1412583..1412897	-	315	WP_005710664.1	YqcC family protein	-
C3363_RS06875	1412939..1413853	-	915	WP_010786650.1	N-acetylmuramic acid 6-phosphate etherase	-
C3363_RS06880	1413865..1414980	-	1116	WP_010786649.1	anhydro-N-acetylmuramic acid kinase	-
C3363_RS06885	1415134..1415469	-	336	WP_010786648.1	outer membrane protein assembly factor BamE	-
C3363_RS06890	1415530..1416531	-	1002	WP_010786647.1	nucleoid-associated protein YejK	-
C3363_RS06895	1416559..1417059	-	501	WP_159179937.1	GNAT family N-acetyltransferase	Toxin
C3363_RS06900	1417049..1417336	-	288	WP_005710653.1	DUF1778 domain-containing protein	Antitoxin
C3363_RS06905	1417482..1417871	+	390	WP_021116694.1	RidA family protein	-
C3363_RS06910	1417875..1418612	+	738	WP_159179938.1	peptidoglycan editing factor PgeF	-
C3363_RS06915	1418787..1420364	+	1578	WP_159179939.1	FAD-binding protein	-
C3363_RS06920	1420471..1420971	+	501	WP_010786633.1	CvpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Vibrio phage ICP1, Orf50 (4-87)

Sequences

Toxin

Protein

• Length: 167 a.a.
• Molecular weight: 19131.32 Da
• Isoelectric Point: 9.2835

>T105052 WP_159179937.1 NZ_CP029150:c1417059-1416559 [Glaesserella parasuis]
MKSKFIEEPLTKHHQREAFDCGNLEMNRFFKQYARQSHEKGTSKTYISRHLDSQQIIGFYTITLSALDQQHLPELCKKRF
GYYPIPLFTLARLAVDIRYQKQGIGGMLLVKAFKRCAIVAEQVGGIGLLIEAKDEDISRWYQSYGAIPLENMLLTLILLF
DTIKGL

Nucleotide

• Length: 501 bp

>T105052 NZ_CP029150:c1417059-1416559 [Glaesserella parasuis]
ATGAAGAGTAAGTTTATTGAAGAGCCTTTAACGAAGCATCATCAACGAGAAGCCTTTGATTGCGGAAATCTAGAGATGAA
CCGATTTTTTAAACAATACGCTCGGCAATCTCACGAAAAAGGGACATCAAAAACTTACATTAGCCGACACTTAGACAGTC
AACAGATTATCGGATTTTATACAATCACCTTAAGTGCATTAGACCAGCAACACTTACCCGAACTATGCAAAAAACGTTTT
GGCTACTACCCTATTCCGCTCTTTACATTAGCAAGACTTGCAGTGGATATTCGCTATCAAAAACAAGGCATTGGCGGAAT
GCTGTTAGTTAAAGCTTTCAAACGCTGTGCCATCGTTGCCGAACAAGTCGGGGGAATTGGGCTTCTCATTGAAGCAAAAG
ATGAAGACATTTCTCGTTGGTATCAATCTTATGGTGCTATTCCATTGGAAAATATGCTATTAACCTTAATTCTACTCTTT
GATACAATCAAAGGACTTTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10917.47 Da
• Isoelectric Point: 6.4650

>AT105052 WP_005710653.1 NZ_CP029150:c1417336-1417049 [Glaesserella parasuis]
MPQIANALNDRMSIRISTEDKQTLIRAVALTHTNITEFVLQRILPSAREIIQQYDNRQFSPQDLSLIMELLDNPPKANTK
LQQAAKLAKESYHEE

Nucleotide

• Length: 288 bp

>AT105052 NZ_CP029150:c1417336-1417049 [Glaesserella parasuis]
ATGCCACAAATTGCAAATGCCCTTAACGATAGAATGTCTATTCGCATTAGTACGGAAGACAAGCAGACTTTAATTAGAGC
CGTTGCACTCACCCATACGAATATTACAGAATTTGTATTACAACGCATTTTGCCTAGTGCCAGAGAAATTATTCAGCAGT
ATGATAATCGGCAATTTTCACCGCAAGATCTCTCGTTGATTATGGAATTGCTTGATAATCCGCCGAAAGCTAATACAAAA
CTACAACAAGCGGCGAAATTAGCAAAGGAAAGCTATCATGAAGAGTAA

Structures

Antitoxin

• AlphaFold DB: U4SPD7