Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1302287..1302915 Replicon chromosome
Accession NZ_CP029150
Organism Glaesserella parasuis strain GZ20170512

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag C3363_RS06325 Protein ID WP_010786741.1
Coordinates 1302287..1302469 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag C3363_RS06330 Protein ID WP_010786740.1
Coordinates 1302502..1302915 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3363_RS06305 1299645..1300187 + 543 WP_010786746.1 hypothetical protein -
C3363_RS06310 1300180..1300602 + 423 WP_010786745.1 type II toxin-antitoxin system YafO family toxin -
C3363_RS06315 1301098..1301475 - 378 WP_010786743.1 anti-termination protein Q, phage associated -
C3363_RS06320 1301472..1302041 - 570 WP_010786742.1 recombination protein NinG -
C3363_RS06325 1302287..1302469 + 183 WP_010786741.1 type II toxin-antitoxin system HicA family toxin Toxin
C3363_RS06330 1302502..1302915 + 414 WP_010786740.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
C3363_RS06335 1302949..1303377 - 429 Protein_1231 recombination protein NinB -
C3363_RS06340 1303460..1304815 - 1356 WP_010786738.1 AAA family ATPase -
C3363_RS06345 1304815..1305195 - 381 WP_010786737.1 hypothetical protein -
C3363_RS06350 1305211..1306197 - 987 WP_005714908.1 IS110 family transposase -
C3363_RS06355 1306335..1306982 - 648 WP_159179933.1 replication protein -
C3363_RS06360 1306960..1307142 - 183 WP_010786733.1 hypothetical protein -
C3363_RS06365 1307481..1307681 - 201 WP_010786732.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1288650..1318662 30012


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-130)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6756.93 Da        Isoelectric Point: 10.7209

>T105051 WP_010786741.1 NZ_CP029150:1302287-1302469 [Glaesserella parasuis]
VDSKTIIKMIEADGWKFHHATGSHHHFTHPIKKGIVTVIHPKKDLKKGTEHSILKQAGLK

Download         Length: 183 bp

>T105051 NZ_CP029150:1302287-1302469 [Glaesserella parasuis]
GTGGATAGCAAAACCATAATTAAAATGATTGAAGCGGACGGTTGGAAATTTCACCATGCAACAGGAAGTCACCACCACTT
CACTCACCCAATCAAAAAAGGCATTGTTACTGTCATTCATCCCAAAAAGGATTTAAAAAAAGGAACAGAACATTCAATAC
TAAAACAAGCGGGGCTAAAATAG

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 15280.41 Da        Isoelectric Point: 4.4693

>AT105051 WP_010786740.1 NZ_CP029150:1302502-1302915 [Glaesserella parasuis]
MLYPIAIEPGDETHAFGVVVPDIPGCFSAGDTLEEAYSNAKEAILGHLELLVELGEEIPMPTSIDNHRKNPDFAEYDFFF
GFVDVDISHLLGKAERINITLPSYLIKRIDDFVAVHKEYKNRSNFLAKIAADKILTA

Download         Length: 414 bp

>AT105051 NZ_CP029150:1302502-1302915 [Glaesserella parasuis]
ATGTTATATCCAATTGCAATCGAACCAGGCGATGAAACCCACGCATTTGGCGTTGTTGTGCCTGATATTCCAGGCTGTTT
CTCTGCCGGCGATACGCTTGAAGAAGCCTACAGCAACGCAAAAGAAGCGATTCTTGGTCATCTTGAGTTATTAGTTGAAC
TTGGCGAAGAAATTCCGATGCCAACCTCCATTGATAACCACCGCAAAAACCCTGATTTTGCAGAATATGACTTCTTTTTC
GGCTTTGTTGATGTTGATATTAGCCATTTACTCGGCAAAGCCGAACGCATCAACATCACCCTCCCTAGCTATCTCATCAA
ACGCATTGATGATTTTGTTGCCGTTCACAAAGAGTATAAAAACCGTAGCAACTTCTTAGCTAAAATCGCAGCGGATAAAA
TCTTAACCGCTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References