Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 719873..720408 Replicon chromosome
Accession NZ_CP029150
Organism Glaesserella parasuis strain GZ20170512

Toxin (Protein)


Gene name relE Uniprot ID B8F327
Locus tag C3363_RS03595 Protein ID WP_012621505.1
Coordinates 720124..720408 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A837AF96
Locus tag C3363_RS03590 Protein ID WP_021118772.1
Coordinates 719873..720127 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3363_RS03570 715425..715967 + 543 WP_010785927.1 adenine phosphoribosyltransferase -
C3363_RS03575 716058..718076 + 2019 WP_159179860.1 DNA polymerase III subunit gamma/tau -
C3363_RS03580 718082..718978 + 897 WP_005712691.1 ABC transporter ATP-binding protein -
C3363_RS03585 719000..719755 + 756 WP_159179861.1 ABC transporter permease -
C3363_RS03590 719873..720127 + 255 WP_021118772.1 hypothetical protein Antitoxin
C3363_RS03595 720124..720408 + 285 WP_012621505.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
C3363_RS03600 720617..722167 + 1551 WP_016528227.1 exodeoxyribonuclease I -
C3363_RS03605 722250..723209 + 960 WP_159179862.1 S-adenosyl-l-methionine hydroxide adenosyltransferase family protein -
C3363_RS03610 723358..724179 + 822 WP_005712684.1 PHP domain-containing protein -
C3363_RS03615 724286..724777 - 492 WP_005712683.1 acetolactate synthase small subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11257.23 Da        Isoelectric Point: 10.4221

>T105049 WP_012621505.1 NZ_CP029150:720124-720408 [Glaesserella parasuis]
MSYTIEFIPSAEKEFRKLSLDLRKQFIEKLKERAENPRVESAKLRGMKDCYKIKLRNAGYRLVYQVIDERIVIKVVAQGK
REHNDVYQKVQLRL

Download         Length: 285 bp

>T105049 NZ_CP029150:720124-720408 [Glaesserella parasuis]
ATGAGCTATACCATTGAATTTATCCCATCAGCAGAAAAAGAGTTTCGTAAACTAAGCTTAGATTTAAGAAAACAATTTAT
CGAAAAACTTAAAGAAAGAGCTGAAAATCCGCGTGTAGAAAGTGCTAAACTTCGTGGAATGAAAGATTGTTATAAAATCA
AATTGCGTAATGCAGGCTATCGTTTGGTGTATCAAGTGATTGATGAACGTATTGTAATCAAAGTGGTTGCACAGGGAAAA
AGGGAGCACAACGACGTTTACCAAAAAGTACAATTACGTTTATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9347.72 Da        Isoelectric Point: 4.4131

>AT105049 WP_021118772.1 NZ_CP029150:719873-720127 [Glaesserella parasuis]
MPSIILTNTVASITELKTNPMATFNAAGGEAIAILNRNEPAFYCVPPHIYEYLIELADDAELAKLVEERQHEKSYKVDLA
DLLK

Download         Length: 255 bp

>AT105049 NZ_CP029150:719873-720127 [Glaesserella parasuis]
ATGCCAAGTATTATTTTAACCAATACCGTTGCGAGTATTACAGAACTAAAGACAAATCCAATGGCGACATTCAATGCGGC
AGGCGGTGAGGCAATTGCAATTTTAAACCGAAATGAACCCGCTTTTTATTGTGTACCACCGCATATTTATGAATATCTCA
TTGAGCTTGCTGATGATGCAGAATTAGCAAAATTAGTGGAAGAACGCCAACACGAAAAAAGCTACAAAGTGGATTTAGCG
GATTTATTAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B8F327

Antitoxin

Source ID Structure
AlphaFold DB A0A837AF96

References