Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 382893..384580 Replicon chromosome
Accession NZ_CP029150
Organism Glaesserella parasuis strain GZ20170512

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag C3363_RS01870 Protein ID WP_159179809.1
Coordinates 382893..384236 (+) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag C3363_RS01875 Protein ID WP_005713145.1
Coordinates 384236..384580 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C3363_RS01845 377894..380071 - 2178 WP_062924260.1 bifunctional 23S rRNA (guanine(2069)-N(7))-methyltransferase RlmK/23S rRNA (guanine(2445)-N(2))-methyltransferase RlmL -
C3363_RS01850 380221..381162 - 942 WP_010787253.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
C3363_RS01855 381245..381658 + 414 WP_005713136.1 DNA polymerase III subunit psi -
C3363_RS01860 381855..382100 + 246 WP_010787254.1 M23 family metallopeptidase -
C3363_RS01865 382342..382779 + 438 WP_010787255.1 ribosomal protein S18-alanine N-acetyltransferase -
C3363_RS01870 382893..384236 + 1344 WP_159179809.1 HipA domain-containing protein Toxin
C3363_RS01875 384236..384580 + 345 WP_005713145.1 helix-turn-helix domain-containing protein Antitoxin
C3363_RS01880 384609..385934 + 1326 WP_159179810.1 ATP-dependent RNA helicase SrmB -
C3363_RS01885 386052..386684 + 633 WP_159179811.1 lipoprotein insertase outer membrane protein LolB -
C3363_RS01890 386686..387531 + 846 WP_015940038.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
C3363_RS01895 387559..388509 + 951 WP_005713153.1 ribose-phosphate pyrophosphokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(161-407)

Antitoxin

Cro/C1-type helix-turn-helix domain

(43-92)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 51076.08 Da        Isoelectric Point: 5.0201

>T105047 WP_159179809.1 NZ_CP029150:382893-384236 [Glaesserella parasuis]
MQIEPLTLQAYIADRWQDIAILTFQADYSLNDFSYLYDLAEILSDNDKAVSFNYPVEFFPHRSVSGWFAFLDDIVPSGAS
RRYWLQKLDIAHLPMAQQNYLLLKQGTIAPVGHLRVKQAVSSFVENEPSRLFEIDDVINRQADFLEYANQRGAMAGGATG
AGGEAPKLLLRQTATQQVWIDNLQQGDAADDFYLVKFPRGKRSAIDCDILRAEFHYYHELASMGFDTIDTTKMWLEEGER
YPSLWLPRFDVYRNEQGKMARYAVESVYAMLEKGAGSLLDHEKVIRQLIAKIETSHLVETGMFFDKQAFVIEWVRRDLLN
IAFGNSDNHGRNTAFLRNQNRIWLAPIYDFAPMKADPEGIPRTTMWDSKGHPALELGGEYRFDLIAEQLDDLCPADKLLD
ALRQTAQQLVGLKARLEARGVPTAILTYPSISLDYLPEKLKRWQLLS

Download         Length: 1344 bp

>T105047 NZ_CP029150:382893-384236 [Glaesserella parasuis]
ATGCAAATCGAACCGCTTACACTTCAGGCCTATATTGCTGATCGTTGGCAGGATATTGCTATTTTGACCTTTCAGGCTGA
TTATAGCCTCAATGATTTTAGCTATCTCTATGATTTAGCAGAGATTTTAAGTGATAATGATAAGGCAGTTTCATTTAACT
ACCCTGTGGAATTTTTTCCGCATCGCAGTGTATCGGGCTGGTTTGCATTTTTAGATGATATAGTCCCTTCTGGGGCAAGC
CGGCGTTATTGGTTGCAAAAACTAGATATTGCTCATTTGCCGATGGCTCAACAAAACTATTTGTTATTAAAACAAGGCAC
GATTGCACCTGTCGGGCATTTACGAGTTAAACAAGCGGTCAGTTCTTTTGTCGAAAATGAACCCTCTCGCTTATTTGAAA
TAGACGATGTTATCAATCGCCAAGCAGACTTTTTGGAATACGCTAATCAGCGTGGGGCAATGGCTGGCGGTGCCACAGGG
GCTGGTGGCGAAGCGCCGAAATTATTGCTACGCCAAACAGCCACTCAGCAAGTTTGGATTGATAATCTACAACAAGGTGA
CGCTGCCGACGATTTCTATTTAGTCAAGTTTCCGCGTGGAAAACGCAGTGCAATAGATTGCGACATATTGAGAGCTGAAT
TTCACTATTACCACGAATTAGCCTCAATGGGTTTTGATACCATTGATACGACAAAAATGTGGTTGGAAGAGGGCGAACGT
TACCCGTCGTTATGGTTACCTCGCTTTGATGTTTATCGTAATGAACAGGGGAAAATGGCTCGTTATGCCGTTGAATCTGT
TTATGCTATGTTAGAAAAAGGGGCTGGCTCTTTGCTGGATCACGAAAAGGTTATTCGTCAGTTGATTGCTAAAATTGAAA
CCTCTCATTTGGTTGAAACAGGAATGTTTTTTGATAAACAGGCTTTTGTGATCGAGTGGGTAAGGCGAGATTTATTGAAT
ATCGCCTTTGGAAATAGCGATAATCACGGACGAAATACGGCTTTCTTACGCAATCAAAATCGTATCTGGCTTGCTCCAAT
TTATGATTTTGCCCCAATGAAAGCAGATCCTGAAGGTATTCCTCGCACGACAATGTGGGATAGTAAAGGTCACCCTGCAT
TAGAATTAGGCGGTGAATATCGTTTTGATCTGATTGCAGAACAGCTTGATGATTTATGTCCAGCCGACAAGTTATTGGAT
GCTTTGCGTCAAACGGCTCAACAGCTTGTCGGACTTAAAGCACGTTTAGAAGCAAGAGGCGTTCCAACGGCAATTTTGAC
GTACCCCTCAATCAGCTTGGACTATTTACCTGAAAAATTAAAACGTTGGCAATTATTATCATAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 13207.48 Da        Isoelectric Point: 10.2782

>AT105047 WP_005713145.1 NZ_CP029150:384236-384580 [Glaesserella parasuis]
MEEIKQARASKSKKTLDIYQRATVRDEIARKLLLNEMSLGQALKYLRLHLLAMKQERYAEIVKVSRKTLSDLENDKGNYS
IDIINQVLRPFELQLGVVPINKTLLRQVLNEQAV

Download         Length: 345 bp

>AT105047 NZ_CP029150:384236-384580 [Glaesserella parasuis]
ATGGAAGAGATCAAACAGGCTAGAGCCTCTAAAAGTAAAAAAACGTTAGATATTTATCAGCGAGCGACTGTGCGAGACGA
AATTGCTCGTAAGCTATTGCTCAATGAGATGAGTTTAGGGCAGGCGTTGAAATATCTACGTTTACATCTACTGGCAATGA
AACAAGAGCGTTATGCGGAGATTGTCAAAGTTTCTCGCAAAACGTTATCTGATTTAGAAAATGATAAGGGCAATTACAGT
ATTGATATTATCAATCAGGTGTTACGCCCCTTTGAATTACAGCTTGGCGTTGTGCCAATAAACAAAACATTACTCAGACA
AGTTTTAAACGAACAAGCGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References