Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 982130..982748 Replicon chromosome
Accession NZ_CP029145
Organism Hymenobacter nivis strain NBRC 111535

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DDQ68_RS04240 Protein ID WP_109655134.1
Coordinates 982130..982378 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DDQ68_RS04245 Protein ID WP_109655136.1
Coordinates 982407..982748 (+) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDQ68_RS04225 978443..978694 - 252 WP_162549823.1 hypothetical protein -
DDQ68_RS04230 978785..979594 - 810 WP_109655131.1 HD domain-containing protein -
DDQ68_RS04235 979766..981667 - 1902 WP_109655133.1 right-handed parallel beta-helix repeat-containing protein -
DDQ68_RS04240 982130..982378 + 249 WP_109655134.1 type II toxin-antitoxin system HicA family toxin Toxin
DDQ68_RS04245 982407..982748 + 342 WP_109655136.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DDQ68_RS04250 982752..983438 + 687 WP_109655138.1 hypothetical protein -
DDQ68_RS04255 983594..985507 + 1914 WP_109658311.1 AAA family ATPase -
DDQ68_RS04260 985630..985893 + 264 WP_109655140.1 hypothetical protein -
DDQ68_RS04265 986015..987157 - 1143 WP_109655142.1 SMP-30/gluconolactonase/LRE family protein -
DDQ68_RS04270 987447..987704 - 258 WP_109655144.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 737634..1320426 582792


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-81)

Antitoxin

Uncharacterised protein family HicB

(55-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9152.83 Da        Isoelectric Point: 10.3509

>T105045 WP_109655134.1 NZ_CP029145:982130-982378 [Hymenobacter nivis]
VAQLDKLRARLCAKPKDFTWDELVKLLAAFGFEALGKGKTAGSRRQFFNPATQVAISMHKPHPGNILKEYQLKEIITLLG
IC

Download         Length: 249 bp

>T105045 NZ_CP029145:982130-982378 [Hymenobacter nivis]
GTGGCCCAACTCGATAAACTGCGGGCCCGGCTCTGTGCCAAGCCCAAGGATTTTACTTGGGACGAGCTGGTGAAGCTGTT
GGCGGCTTTCGGCTTCGAGGCCCTGGGCAAGGGCAAAACGGCGGGCAGCCGCCGGCAATTTTTCAATCCGGCGACCCAGG
TTGCCATCAGTATGCACAAACCGCATCCGGGCAACATTCTCAAAGAATACCAACTCAAGGAAATTATCACCCTGCTGGGC
ATTTGCTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12351.94 Da        Isoelectric Point: 5.6925

>AT105045 WP_109655136.1 NZ_CP029145:982407-982748 [Hymenobacter nivis]
MENGLIYKSYVGSVQYNATDEIFHGKIEAITDLVTFEADSAKQLRPEFEQAVDDYLALCAAVGKAPNKTFTGSFNVRLGP
ELHRKAALVSTGRGISLNQLVSQAVRQFVTQGE

Download         Length: 342 bp

>AT105045 NZ_CP029145:982407-982748 [Hymenobacter nivis]
ATGGAAAACGGACTCATCTATAAAAGCTACGTCGGCTCGGTACAGTACAATGCGACCGATGAGATTTTCCACGGCAAAAT
CGAAGCCATCACCGATTTGGTGACGTTTGAGGCCGATTCGGCCAAGCAGCTCCGGCCCGAGTTTGAGCAGGCTGTGGACG
ATTATCTGGCGCTGTGCGCCGCGGTAGGCAAGGCCCCCAACAAGACCTTCACGGGCAGCTTCAACGTGCGCCTGGGCCCC
GAGTTACACCGCAAAGCCGCGCTGGTTTCTACGGGCCGAGGCATCAGTCTCAACCAACTGGTGAGCCAGGCCGTCCGCCA
ATTTGTGACGCAAGGTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References