Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1110814..1111471 Replicon chromosome
Accession NZ_CP029137
Organism Klebsiella pneumoniae strain AR376

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag CSC13_RS07165 Protein ID WP_002916310.1
Coordinates 1111061..1111471 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag CSC13_RS07160 Protein ID WP_002916312.1
Coordinates 1110814..1111080 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC13_RS07135 1105970..1107403 - 1434 WP_020324925.1 6-phospho-beta-glucosidase -
CSC13_RS07140 1107522..1108250 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
CSC13_RS07145 1108300..1108611 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
CSC13_RS07150 1108775..1109434 + 660 WP_002916317.1 hemolysin III family protein -
CSC13_RS07155 1109585..1110568 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
CSC13_RS07160 1110814..1111080 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
CSC13_RS07165 1111061..1111471 + 411 WP_002916310.1 protein YgfX Toxin
CSC13_RS07170 1111478..1111999 - 522 WP_004144730.1 flavodoxin FldB -
CSC13_RS07175 1112100..1112996 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
CSC13_RS07180 1113019..1113732 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CSC13_RS07185 1113738..1115471 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T105032 WP_002916310.1 NZ_CP029137:1111061-1111471 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T105032 NZ_CP029137:1111061-1111471 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAAATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT105032 WP_002916312.1 NZ_CP029137:1110814-1111080 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT105032 NZ_CP029137:1110814-1111080 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References