Detailed information of TA system TA105024

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3860772..3861471
• Replicon: chromosome
• Accession: NZ_CP029133
• Organism: Proteus mirabilis strain AR379

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: CSC16_RS18310
• Protein ID: WP_004249093.1
• Coordinates: 3861085..3861471 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: CSC16_RS18305
• Protein ID: WP_004246828.1
• Coordinates: 3860772..3861092 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC16_RS18275	3855899..3856174	-	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-
CSC16_RS18280	3856229..3856852	-	624	WP_004246821.1	guanylate kinase	-
CSC16_RS18285	3857154..3857771	-	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
CSC16_RS18290	3857908..3859194	+	1287	WP_036919265.1	DUF3748 domain-containing protein	-
CSC16_RS18295	3859412..3860296	+	885	WP_004249091.1	endonuclease/exonuclease/phosphatase family protein	-
CSC16_RS18300	3860289..3860723	+	435	WP_020946391.1	hypothetical protein	-
CSC16_RS18305	3860772..3861092	-	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
CSC16_RS18310	3861085..3861471	-	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CSC16_RS18315	3861633..3863705	-	2073	WP_017827114.1	glycine--tRNA ligase subunit beta	-
CSC16_RS18320	3863715..3864620	-	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
CSC16_RS18325	3864871..3865452	+	582	WP_012368524.1	DNA-3-methyladenine glycosylase I	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T105024 WP_004249093.1 NZ_CP029133:c3861471-3861085 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T105024 NZ_CP029133:c3861471-3861085 [Proteus mirabilis]
ATGGTTATTTATAAAACAAAGATGTTCAAAAATAGTTTCAAAAAAATAACGCTTACGAATGCAGAACTAATAGCTATCGC
TACCGAAGTCCTTGCAGGACAATTTGAGGCAGATCTAGGTGGTGGTGTTATCAAGAAACGTGCCTGTATCCAAGGAAAAG
GTAAAAGTAGCGGAATTAGAACAATTATATTTTATAAGCAAGGGAATAATTTATTCTTTGCTGATGGTTGGAAAAAATCG
AGTTTAAGCTCTAAAAAAACCAAAGAGATCACAGATGATGAACTTGAGTCCTATAAAGATCTAGCAAAAGATCTCTTCAA
TGCAAATCAAAATAAAATAGATAAAATGATTGCACTAGGCCTTTTAACAGAGGTTAAATATGACTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT105024 WP_004246828.1 NZ_CP029133:c3861092-3860772 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT105024 NZ_CP029133:c3861092-3860772 [Proteus mirabilis]
ATGACTGATAAAATGAAAGAAATGCTAAAATTTGCACAAGAAATGGAAGATGCAGGAGTCACTGATGGCAGTACAACTAA
ACGAATTGCCGCCAGAATAAAAGCGAAAGAATTACAAGCTAAGTATAAACATCCTACCCCTATGACAGGTGAAGATATAA
AAAGGATCCGTGAGCAAAATAATATCTCTCAATCTTCCCTTGCTTTGATATTGAATATGACTAAAGAAAGCGTTTCTAAG
TGGGAAAGAAACGAAATTAAGCCCAATGGTGCAGCACTACGACTTCTGCATTTAATAGATAAAAAAATATTATTCATCTA
G

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97