Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3529976..3530577 Replicon chromosome
Accession NZ_CP029133
Organism Proteus mirabilis strain AR379

Toxin (Protein)


Gene name doc Uniprot ID A0A1Z1SQZ4
Locus tag CSC16_RS16805 Protein ID WP_036895893.1
Coordinates 3530194..3530577 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag CSC16_RS16800 Protein ID WP_004246496.1
Coordinates 3529976..3530197 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC16_RS16775 3525761..3526219 + 459 WP_004246490.1 dUTP diphosphatase -
CSC16_RS16780 3526339..3526944 + 606 WP_004246491.1 nucleoid occlusion factor SlmA -
CSC16_RS16785 3527263..3527907 - 645 WP_060555873.1 orotate phosphoribosyltransferase -
CSC16_RS16790 3527989..3528705 - 717 WP_004249760.1 ribonuclease PH -
CSC16_RS16795 3528832..3529695 + 864 WP_004249947.1 YicC family protein -
CSC16_RS16800 3529976..3530197 + 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
CSC16_RS16805 3530194..3530577 + 384 WP_036895893.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
CSC16_RS16810 3530984..3531298 + 315 WP_004246498.1 helix-turn-helix domain-containing protein -
CSC16_RS16815 3531311..3532549 + 1239 WP_060555874.1 HipA domain-containing protein -
CSC16_RS16820 3532906..3533805 - 900 WP_004246500.1 N-acetylmuramic acid 6-phosphate etherase -
CSC16_RS16825 3534081..3534644 - 564 WP_012368640.1 methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(2-125)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14518.52 Da        Isoelectric Point: 8.4945

>T105022 WP_036895893.1 NZ_CP029133:3530194-3530577 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGRIFNDGNKRTAFFVT
MTFLYRNGIRIRDTDNTLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T105022 NZ_CP029133:3530194-3530577 [Proteus mirabilis]
ATGATATGGGTTAGCGCACAGGAAGTTATCGCTTTCCATGATCGTATATTACAACGTTTCCCAGGTGTGGCCGGTATGTC
CGATCCTGGCAGAGCGGAAGCTCTTATTTACCGGGTGCAAAACCGTAAACATTATGAAGGCATTACAGATGTGTTTGAAC
TGGCAGCAACTTATTGGGTCGCTATCGCTCGAGGGCGCATATTTAATGACGGTAATAAACGTACCGCATTTTTTGTGACC
ATGACATTTCTCTATCGTAATGGCATCAGGATCCGCGATACCGACAATACGCTGGAAAACTTAACAGTGGAAGCGGCTAC
AGGTGAGAAAACCGTCGACCAGTTAGCAAAACATCTACAAAACTTGGTAGAGAAAACTAACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT105022 WP_004246496.1 NZ_CP029133:3529976-3530197 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT105022 NZ_CP029133:3529976-3530197 [Proteus mirabilis]
ATGCGTACATATACCTCGACACAAGCCCGAGCCAATATCTCAGAAGTATTAGATATTGCGACCCACGGTGAACCTGTTGA
AATCACCCGCAGAGACGGTTGTTCAGCAGTTGTTATCAGTAAAACTGAATTTGAGTCATACCAGAATGCTAAGCTAGATG
CAGAGTTTGATATGATGATGCAACGTCATGGACATACCGTAGAGGCGCTGACAAATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Z1SQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References