Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4017064..4017721 Replicon chromosome
Accession NZ_CP029128
Organism Klebsiella oxytoca strain AR380

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag CSC17_RS19885 Protein ID WP_004105559.1
Coordinates 4017311..4017721 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag CSC17_RS19880 Protein ID WP_004105561.1
Coordinates 4017064..4017330 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC17_RS19855 4012243..4013676 - 1434 WP_004105576.1 6-phospho-beta-glucosidase -
CSC17_RS19860 4013797..4014525 - 729 WP_064352017.1 MurR/RpiR family transcriptional regulator -
CSC17_RS19865 4014576..4014887 + 312 WP_004105571.1 N(4)-acetylcytidine aminohydrolase -
CSC17_RS19870 4015049..4015708 + 660 WP_064344096.1 hemolysin III family protein -
CSC17_RS19875 4015837..4016820 - 984 WP_108704559.1 tRNA-modifying protein YgfZ -
CSC17_RS19880 4017064..4017330 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
CSC17_RS19885 4017311..4017721 + 411 WP_004105559.1 protein YgfX Toxin
CSC17_RS19890 4017730..4018251 - 522 WP_108704560.1 flavodoxin FldB -
CSC17_RS19895 4018373..4019269 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
CSC17_RS19900 4019292..4020005 + 714 WP_004105554.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CSC17_RS19905 4020011..4021744 + 1734 WP_024274698.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T105013 WP_004105559.1 NZ_CP029128:4017311-4017721 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

>T105013 NZ_CP029128:4017311-4017721 [Klebsiella oxytoca]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAATGGTTCTCACTGTTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGGTGTTGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGACAGGGGGAAATAAAGCTGCTGATTGACTCTCGCCTGCGCTGGCAAAAAGCG
GAGTGGGATATCGTCGGCACCCCGTGGGTAATTAATAGCGGAATGCTGCTGCGCCTGAGAAATACGGAAAACCAACGCAC
TCAGCATCTATGGGTGGCGGCGGATAGCATGGACGCGGGCGAGTGGCGCGATCTGCGTCGGCTGGTGTTACAGAAACCGA
CGCAAGATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT105013 WP_004105561.1 NZ_CP029128:4017064-4017330 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT105013 NZ_CP029128:4017064-4017330 [Klebsiella oxytoca]
ATGGATATTAACAATAAAGCTCGCATCCACTGGGCATGCCGCCGGGGAATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTTGAGCATGAGTACGATACGCTCAGTGATGACGATAAGCGGTTGTTCATCCGCCTGCTGGAAAATGACGATCCGGACC
TGTTCAACTGGTTGATGAACCATGGCGAACCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References