Detailed information of TA system TA105011

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 3188294..3189066
• Replicon: chromosome
• Accession: NZ_CP029128
• Organism: Klebsiella oxytoca strain AR380

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: CSC17_RS15745
• Protein ID: WP_108704383.1
• Coordinates: 3188294..3188683 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: CSC17_RS15750
• Protein ID: WP_204101137.1
• Coordinates: 3188740..3189066 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC17_RS15715	3183573..3183875	-	303	WP_049127699.1	antibiotic biosynthesis monooxygenase	-
CSC17_RS15720	3183877..3184884	-	1008	WP_017145218.1	zinc-binding alcohol dehydrogenase family protein	-
CSC17_RS15725	3184997..3185464	-	468	WP_064344103.1	DUF3237 domain-containing protein	-
CSC17_RS15730	3185665..3186120	+	456	WP_004106993.1	helix-turn-helix domain-containing protein	-
CSC17_RS15735	3186120..3186695	+	576	WP_017145221.1	PIN domain-containing protein	-
CSC17_RS15740	3187362..3188207	-	846	WP_108704382.1	DUF4942 domain-containing protein	-
CSC17_RS15745	3188294..3188683	-	390	WP_108704383.1	TA system toxin CbtA family protein	Toxin
CSC17_RS15750	3188740..3189066	-	327	WP_204101137.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CSC17_RS15755	3189124..3189345	-	222	WP_108704385.1	DUF987 family protein	-
CSC17_RS15760	3189359..3189845	-	487	Protein_2902	DNA repair protein RadC	-
CSC17_RS15765	3189857..3190306	-	450	WP_108704386.1	antirestriction protein	-
CSC17_RS15770	3190339..3191160	-	822	WP_108704387.1	DUF945 domain-containing protein	-
CSC17_RS15775	3191496..3192446	-	951	WP_108704388.1	hypothetical protein	-
CSC17_RS15780	3193031..3193642	+	612	WP_108705051.1	inovirus Gp2 family protein	-
CSC17_RS15785	3193755..3193973	+	219	WP_108705052.1	AlpA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimA / fimC / fimD / fimG	3186120..3216925	30805

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14272.25 Da
• Isoelectric Point: 9.5904

>T105011 WP_108704383.1 NZ_CP029128:c3188683-3188294 [Klebsiella oxytoca]
MQTKSSSLMRAASSRPSPVDVWQALLTSLLAQHYSLTLSDTPFSDEQVIQQHIDAGISLADALNFIVEKYELVRTDRPGF
SIIEQSPFITAIDILRARKVTGLMNRGTYKEVTAITRGQHPQANASGKR

Nucleotide

• Length: 390 bp

>T105011 NZ_CP029128:c3188683-3188294 [Klebsiella oxytoca]
ATGCAAACCAAATCATCCTCCCTCATGCGGGCGGCATCGTCACGTCCGTCTCCCGTTGATGTCTGGCAGGCTCTGCTGAC
CAGCCTGCTGGCACAACACTATAGCCTCACGCTTAGCGATACGCCGTTCAGTGATGAACAGGTGATTCAGCAACATATCG
ACGCGGGTATCTCGCTGGCCGATGCCCTGAATTTTATTGTAGAGAAGTACGAACTGGTCCGTACTGACCGGCCAGGCTTC
AGCATCATAGAGCAGTCTCCGTTTATTACGGCCATTGATATTCTCCGGGCCAGAAAGGTTACAGGGCTGATGAACCGTGG
CACGTATAAAGAGGTGACGGCTATTACCAGAGGACAACATCCGCAGGCCAACGCTTCAGGCAAGCGATGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12192.86 Da
• Isoelectric Point: 6.6292

>AT105011 WP_204101137.1 NZ_CP029128:c3189066-3188740 [Klebsiella oxytoca]
ISEPWWGLRRSVSPCFGARLVQEGNRLHYLADRANFDGKFCDADLRHLDQSFPVLMKQLELMLTSGELNPRHQHSVTLYA
KGLACEADTLGSHGYVYIAIYPTPVTTE

Nucleotide

• Length: 327 bp

>AT105011 NZ_CP029128:c3189066-3188740 [Klebsiella oxytoca]
ATCAGCGAACCCTGGTGGGGGCTAAGACGCAGTGTCTCCCCGTGTTTTGGGGCCCGTCTGGTCCAGGAGGGAAATCGCCT
GCATTACCTGGCTGACCGGGCGAACTTTGATGGTAAGTTCTGTGATGCGGATTTGCGCCATCTTGACCAGTCTTTCCCGG
TACTGATGAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTGAATCCCCGTCATCAGCACAGCGTCACACTGTATGCA
AAAGGTCTGGCCTGCGAGGCCGATACGCTCGGTTCGCATGGCTACGTTTATATCGCGATTTATCCCACTCCCGTCACCAC
AGAATAA