105010

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 3185665..3186695 Replicon chromosome
Accession NZ_CP029128
Organism Klebsiella oxytoca strain AR380

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag CSC17_RS15735 Protein ID WP_017145221.1
Coordinates 3186120..3186695 (+) Length 192 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag CSC17_RS15730 Protein ID WP_004106993.1
Coordinates 3185665..3186120 (+) Length 152 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC17_RS15705 3181415..3182368 + 954 WP_108704381.1 helix-turn-helix domain-containing protein -
CSC17_RS15710 3182365..3183414 - 1050 WP_004107002.1 NAD(P)-dependent alcohol dehydrogenase -
CSC17_RS15715 3183573..3183875 - 303 WP_049127699.1 antibiotic biosynthesis monooxygenase -
CSC17_RS15720 3183877..3184884 - 1008 WP_017145218.1 zinc-binding alcohol dehydrogenase family protein -
CSC17_RS15725 3184997..3185464 - 468 WP_064344103.1 DUF3237 domain-containing protein -
CSC17_RS15730 3185665..3186120 + 456 WP_004106993.1 helix-turn-helix domain-containing protein Antitoxin
CSC17_RS15735 3186120..3186695 + 576 WP_017145221.1 PIN domain-containing protein Toxin
CSC17_RS15740 3187362..3188207 - 846 WP_108704382.1 DUF4942 domain-containing protein -
CSC17_RS15745 3188294..3188683 - 390 WP_108704383.1 TA system toxin CbtA family protein -
CSC17_RS15750 3188740..3189066 - 327 WP_204101137.1 type IV toxin-antitoxin system YeeU family antitoxin -
CSC17_RS15755 3189124..3189345 - 222 WP_108704385.1 DUF987 family protein -
CSC17_RS15760 3189359..3189845 - 487 Protein_2902 DNA repair protein RadC -
CSC17_RS15765 3189857..3190306 - 450 WP_108704386.1 antirestriction protein -
CSC17_RS15770 3190339..3191160 - 822 WP_108704387.1 DUF945 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-115)

Antitoxin

Helix-turn-helix domain, group 17

(82-130)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 21806.46 Da        Isoelectric Point: 6.9659

>T105010 WP_017145221.1 NZ_CP029128:3186120-3186695 [Klebsiella oxytoca]
MRHSPYPVILDACVLYPARLRDLLMHLGIAGLYQPKWSRCIQDEWCRNLIANRPDILPETLQRTVKMMNSALPDANVTGY
KGLISNLHLPDPNDRHVLAAAIRAKAEIIVTLNHKDFPPELLGPYEIETLHPDAFISDLFDLNHALTLEAVRRQRLSLKH
PSMAVDEFLEMLLKQGLPMTVKELAHYQYAI

Download         Length: 576 bp

>T105010 NZ_CP029128:3186120-3186695 [Klebsiella oxytoca]
ATGCGACATTCACCTTATCCGGTGATTTTAGATGCCTGTGTGTTATATCCGGCACGACTCAGAGATTTGCTGATGCACCT
GGGGATTGCCGGGCTGTATCAACCAAAATGGAGCCGCTGCATTCAGGATGAATGGTGCAGAAACTTGATTGCTAATCGGC
CTGACATTCTGCCAGAGACGCTTCAGCGTACTGTCAAAATGATGAATTCCGCCTTACCAGATGCCAATGTTACGGGATAT
AAGGGATTAATAAGTAATCTGCATCTGCCGGATCCCAACGACAGACATGTTCTTGCCGCAGCGATAAGAGCGAAAGCTGA
AATTATTGTAACGCTTAACCATAAGGACTTTCCGCCAGAACTTCTGGGTCCATATGAAATAGAAACGCTTCACCCTGATG
CGTTTATTTCCGATCTCTTCGATCTTAATCATGCTCTGACGCTTGAAGCCGTCAGGCGGCAGCGACTGTCTCTAAAACAT
CCATCTATGGCGGTCGATGAATTTCTTGAAATGCTGCTAAAGCAGGGTTTACCGATGACGGTAAAGGAATTAGCGCATTA
TCAGTATGCTATTTAA

Antitoxin


Download         Length: 152 a.a.        Molecular weight: 17068.56 Da        Isoelectric Point: 6.4953

>AT105010 WP_004106993.1 NZ_CP029128:3185665-3186120 [Klebsiella oxytoca]
MTTLTHLNLPDRQESELAQRGQRELAAYLSTRLETQRIAIVGEDDKAHTIELPTSALTLLMEILGELASGNAVQIVPVHA
ELTTQEAANILNVSRPHMVKLLEARKLPFHKTGRHRRVLFADLMEYKKRREQESLDAMQSLADQAQDLGMY

Download         Length: 456 bp

>AT105010 NZ_CP029128:3185665-3186120 [Klebsiella oxytoca]
ATGACTACACTGACTCATCTCAACCTTCCCGATCGCCAGGAGAGCGAACTTGCGCAGCGCGGACAGCGTGAGCTTGCGGC
GTATCTTTCCACCAGGCTGGAAACACAGCGTATTGCCATTGTAGGAGAGGATGATAAAGCTCATACCATAGAGCTACCTA
CAAGTGCGCTGACATTGCTGATGGAGATATTGGGGGAGTTGGCTAGCGGAAATGCGGTACAAATCGTTCCCGTACATGCG
GAACTCACAACCCAGGAGGCGGCAAATATACTCAATGTCTCTCGTCCGCATATGGTTAAGCTCCTGGAAGCGAGGAAGCT
CCCATTTCATAAAACGGGGCGTCATCGCAGAGTGTTGTTTGCCGATCTTATGGAGTATAAGAAACGCAGGGAACAGGAGA
GCCTGGACGCGATGCAATCATTGGCCGATCAGGCGCAGGACTTAGGGATGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References