Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 3162582..3163129 | Replicon | chromosome |
Accession | NZ_CP029128 | ||
Organism | Klebsiella oxytoca strain AR380 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | - |
Locus tag | CSC17_RS15615 | Protein ID | WP_064344021.1 |
Coordinates | 3162582..3162890 (-) | Length | 103 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | - |
Locus tag | CSC17_RS15620 | Protein ID | WP_064344020.1 |
Coordinates | 3162893..3163129 (-) | Length | 79 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
CSC17_RS15590 | 3158486..3158797 | - | 312 | WP_108704375.1 | PTS sugar transporter subunit IIB | - |
CSC17_RS15595 | 3159092..3160033 | + | 942 | WP_004107045.1 | LacI family transcriptional regulator | - |
CSC17_RS15600 | 3160057..3160350 | - | 294 | WP_016809978.1 | hypothetical protein | - |
CSC17_RS15605 | 3160564..3161526 | + | 963 | WP_024274836.1 | Rpn family recombination-promoting nuclease/putative transposase | - |
CSC17_RS15610 | 3161530..3162432 | - | 903 | WP_004107039.1 | DMT family transporter | - |
CSC17_RS15615 | 3162582..3162890 | - | 309 | WP_064344021.1 | CcdB family protein | Toxin |
CSC17_RS15620 | 3162893..3163129 | - | 237 | WP_064344020.1 | type II toxin-antitoxin system CcdA family antitoxin | Antitoxin |
CSC17_RS15625 | 3163235..3164668 | - | 1434 | WP_064370664.1 | PTS N-acetylmuramic acid transporter subunit IIBC | - |
CSC17_RS15630 | 3164693..3165595 | - | 903 | WP_108704376.1 | N-acetylmuramic acid 6-phosphate etherase | - |
CSC17_RS15635 | 3165757..3166923 | - | 1167 | WP_004107034.1 | multidrug effflux MFS transporter | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 103 a.a. Molecular weight: 11726.51 Da Isoelectric Point: 6.2188
>T105009 WP_064344021.1 NZ_CP029128:c3162890-3162582 [Klebsiella oxytoca]
MQYYVYKNTGRIAAYPYLLDVQSDIIGERNTRVVIPLFPLKNYKGPRADRLTPLVTVEGEEYVVMTHELASIPHRVLGEE
VCNLNHQREVVKASMDFLFDGI
MQYYVYKNTGRIAAYPYLLDVQSDIIGERNTRVVIPLFPLKNYKGPRADRLTPLVTVEGEEYVVMTHELASIPHRVLGEE
VCNLNHQREVVKASMDFLFDGI
Download Length: 309 bp
>T105009 NZ_CP029128:c3162890-3162582 [Klebsiella oxytoca]
ATGCAGTATTACGTTTATAAGAATACAGGTCGAATTGCTGCGTATCCTTACCTCCTTGATGTACAGAGTGACATTATCGG
CGAGCGCAATACTCGGGTTGTGATTCCACTGTTTCCACTGAAAAACTATAAAGGTCCACGCGCCGATCGTTTAACACCGC
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGCATCCCACATCGTGTTCTGGGTGAAGAG
GTTTGTAATCTGAATCACCAGCGCGAAGTCGTTAAAGCTTCAATGGATTTTCTTTTCGACGGGATCTAA
ATGCAGTATTACGTTTATAAGAATACAGGTCGAATTGCTGCGTATCCTTACCTCCTTGATGTACAGAGTGACATTATCGG
CGAGCGCAATACTCGGGTTGTGATTCCACTGTTTCCACTGAAAAACTATAAAGGTCCACGCGCCGATCGTTTAACACCGC
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGCATCCCACATCGTGTTCTGGGTGAAGAG
GTTTGTAATCTGAATCACCAGCGCGAAGTCGTTAAAGCTTCAATGGATTTTCTTTTCGACGGGATCTAA
Antitoxin
Download Length: 79 a.a. Molecular weight: 8768.95 Da Isoelectric Point: 5.7928
>AT105009 WP_064344020.1 NZ_CP029128:c3163129-3162893 [Klebsiella oxytoca]
MPAAKRNKQNVSVTLDPGLVKQAREVGINLSLTLTNALKSEIHSLEIARWQKENALAIDYLNNLTEENGLLSDEYRTF
MPAAKRNKQNVSVTLDPGLVKQAREVGINLSLTLTNALKSEIHSLEIARWQKENALAIDYLNNLTEENGLLSDEYRTF
Download Length: 237 bp
>AT105009 NZ_CP029128:c3163129-3162893 [Klebsiella oxytoca]
ATGCCAGCCGCAAAACGCAATAAGCAGAACGTCAGCGTGACACTGGACCCTGGCCTGGTCAAACAGGCTCGTGAGGTCGG
CATCAATCTGTCTCTAACGTTGACTAACGCTCTAAAAAGCGAAATCCACAGCCTCGAAATAGCCCGCTGGCAAAAAGAAA
ATGCCCTGGCAATCGACTACCTCAATAATTTAACTGAGGAAAATGGACTTCTCTCTGATGAATACAGGACGTTCTAA
ATGCCAGCCGCAAAACGCAATAAGCAGAACGTCAGCGTGACACTGGACCCTGGCCTGGTCAAACAGGCTCGTGAGGTCGG
CATCAATCTGTCTCTAACGTTGACTAACGCTCTAAAAAGCGAAATCCACAGCCTCGAAATAGCCCGCTGGCAAAAAGAAA
ATGCCCTGGCAATCGACTACCTCAATAATTTAACTGAGGAAAATGGACTTCTCTCTGATGAATACAGGACGTTCTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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