Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3162582..3163129 Replicon chromosome
Accession NZ_CP029128
Organism Klebsiella oxytoca strain AR380

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag CSC17_RS15615 Protein ID WP_064344021.1
Coordinates 3162582..3162890 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag CSC17_RS15620 Protein ID WP_064344020.1
Coordinates 3162893..3163129 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC17_RS15590 3158486..3158797 - 312 WP_108704375.1 PTS sugar transporter subunit IIB -
CSC17_RS15595 3159092..3160033 + 942 WP_004107045.1 LacI family transcriptional regulator -
CSC17_RS15600 3160057..3160350 - 294 WP_016809978.1 hypothetical protein -
CSC17_RS15605 3160564..3161526 + 963 WP_024274836.1 Rpn family recombination-promoting nuclease/putative transposase -
CSC17_RS15610 3161530..3162432 - 903 WP_004107039.1 DMT family transporter -
CSC17_RS15615 3162582..3162890 - 309 WP_064344021.1 CcdB family protein Toxin
CSC17_RS15620 3162893..3163129 - 237 WP_064344020.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
CSC17_RS15625 3163235..3164668 - 1434 WP_064370664.1 PTS N-acetylmuramic acid transporter subunit IIBC -
CSC17_RS15630 3164693..3165595 - 903 WP_108704376.1 N-acetylmuramic acid 6-phosphate etherase -
CSC17_RS15635 3165757..3166923 - 1167 WP_004107034.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11726.51 Da        Isoelectric Point: 6.2188

>T105009 WP_064344021.1 NZ_CP029128:c3162890-3162582 [Klebsiella oxytoca]
MQYYVYKNTGRIAAYPYLLDVQSDIIGERNTRVVIPLFPLKNYKGPRADRLTPLVTVEGEEYVVMTHELASIPHRVLGEE
VCNLNHQREVVKASMDFLFDGI

Download         Length: 309 bp

>T105009 NZ_CP029128:c3162890-3162582 [Klebsiella oxytoca]
ATGCAGTATTACGTTTATAAGAATACAGGTCGAATTGCTGCGTATCCTTACCTCCTTGATGTACAGAGTGACATTATCGG
CGAGCGCAATACTCGGGTTGTGATTCCACTGTTTCCACTGAAAAACTATAAAGGTCCACGCGCCGATCGTTTAACACCGC
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGCATCCCACATCGTGTTCTGGGTGAAGAG
GTTTGTAATCTGAATCACCAGCGCGAAGTCGTTAAAGCTTCAATGGATTTTCTTTTCGACGGGATCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8768.95 Da        Isoelectric Point: 5.7928

>AT105009 WP_064344020.1 NZ_CP029128:c3163129-3162893 [Klebsiella oxytoca]
MPAAKRNKQNVSVTLDPGLVKQAREVGINLSLTLTNALKSEIHSLEIARWQKENALAIDYLNNLTEENGLLSDEYRTF

Download         Length: 237 bp

>AT105009 NZ_CP029128:c3163129-3162893 [Klebsiella oxytoca]
ATGCCAGCCGCAAAACGCAATAAGCAGAACGTCAGCGTGACACTGGACCCTGGCCTGGTCAAACAGGCTCGTGAGGTCGG
CATCAATCTGTCTCTAACGTTGACTAACGCTCTAAAAAGCGAAATCCACAGCCTCGAAATAGCCCGCTGGCAAAAAGAAA
ATGCCCTGGCAATCGACTACCTCAATAATTTAACTGAGGAAAATGGACTTCTCTCTGATGAATACAGGACGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References