Detailed information of TA system TA105006

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 1887494..1888313
• Replicon: chromosome
• Accession: NZ_CP029128
• Organism: Klebsiella oxytoca strain AR380

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: CSC17_RS09485
• Protein ID: WP_004110819.1
• Coordinates: 1888056..1888313 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: CSC17_RS09480
• Protein ID: WP_016809596.1
• Coordinates: 1887494..1888045 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC17_RS09465	1882564..1883112	-	549	WP_004099233.1	type 1 fimbrial major subunit FimA	-
CSC17_RS09470	1883485..1884252	+	768	WP_004099232.1	winged helix-turn-helix domain-containing protein	-
CSC17_RS29340	1884880..1885557	+	678	WP_135800006.1	hypothetical protein	-
CSC17_RS09475	1885848..1887476	-	1629	WP_023329287.1	SAM-dependent methyltransferase	-
CSC17_RS09480	1887494..1888045	-	552	WP_016809596.1	N-acetyltransferase	Antitoxin
CSC17_RS09485	1888056..1888313	-	258	WP_004110819.1	YjhX family toxin	Toxin
CSC17_RS09490	1888895..1890079	+	1185	WP_004099225.1	mannonate dehydratase	-
CSC17_RS09495	1890154..1891629	+	1476	WP_108704179.1	fructuronate reductase	-
CSC17_RS09500	1891765..1892541	+	777	WP_004099223.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (17-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T105006 WP_004110819.1 NZ_CP029128:c1888313-1888056 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T105006 NZ_CP029128:c1888313-1888056 [Klebsiella oxytoca]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCATATTCGCGATGCATC
AGGCCGCGTAACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAACTCATTAAGTCCGTCAACGGGCAGCCCTACCGTATCAATACCACCGGGCTGAACAACGTTCGCGCT
CAGCTGGACAACCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20169.01 Da
• Isoelectric Point: 6.8799

>AT105006 WP_016809596.1 NZ_CP029128:c1888045-1887494 [Klebsiella oxytoca]
MTNHNFTFHITSERDADDIREVETRAFGFSKEADLVAALLNDESAHPSLSLLAKHNGKAVGHILFTLATFKGESDSPMMH
ILAPLAVVPEYQGVGVGGLLIQRGIEHLKAAGSEAVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMLQRLSS
RPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT105006 NZ_CP029128:c1888045-1887494 [Klebsiella oxytoca]
ATGACAAACCATAACTTCACCTTTCACATCACCTCAGAGCGTGATGCTGATGATATTCGCGAAGTTGAAACCCGGGCCTT
CGGCTTTAGCAAAGAGGCCGATCTGGTTGCCGCTTTGCTCAACGATGAAAGTGCTCACCCGAGCTTATCTCTGCTGGCCA
AACATAATGGAAAAGCCGTTGGGCATATTTTGTTCACCCTGGCGACGTTCAAAGGGGAGTCTGACTCTCCGATGATGCAT
ATCCTTGCCCCCCTGGCGGTGGTGCCGGAATACCAGGGCGTGGGCGTAGGCGGATTGCTTATCCAGCGCGGTATTGAGCA
TCTGAAAGCCGCAGGAAGCGAGGCGGTATTTGTTCTGGGACATGCCACTTATTACCCGCGGCATGGCTTTGAACCCTGTG
CCGGAGATAAAGGCTATCCGGCGCCTTATCCCATTCCCGAGGAGCATAAAGCCTGCTGGATGCTGCAGCGGCTTTCGTCC
CGGCCGCTGGGGAGAACCGGTCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2