105005

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1624616..1625235 Replicon chromosome
Accession NZ_CP029128
Organism Klebsiella oxytoca strain AR380

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag CSC17_RS08235 Protein ID WP_004099646.1
Coordinates 1625017..1625235 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag CSC17_RS08230 Protein ID WP_108704142.1
Coordinates 1624616..1624990 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC17_RS08220 1619772..1620965 + 1194 WP_004111040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
CSC17_RS08225 1620988..1624134 + 3147 WP_004099650.1 multidrug efflux RND transporter permease subunit -
CSC17_RS08230 1624616..1624990 + 375 WP_108704142.1 Hha toxicity modulator TomB Antitoxin
CSC17_RS08235 1625017..1625235 + 219 WP_004099646.1 hemolysin expression modulator Hha Toxin
CSC17_RS08240 1625396..1625962 + 567 WP_023320460.1 maltose O-acetyltransferase -
CSC17_RS08245 1626099..1626569 + 471 WP_004111038.1 YlaC family protein -
CSC17_RS08250 1626544..1627998 - 1455 WP_070557208.1 PLP-dependent aminotransferase family protein -
CSC17_RS08255 1628101..1628799 + 699 WP_004099639.1 GNAT family N-acetyltransferase -
CSC17_RS08260 1628796..1628936 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
CSC17_RS08265 1628936..1629199 - 264 WP_004099638.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T105005 WP_004099646.1 NZ_CP029128:1625017-1625235 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T105005 NZ_CP029128:1625017-1625235 [Klebsiella oxytoca]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGCTTACGACGTTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCTGATAATGAACTGGCGGTATTTTACTCAGCAGCCGATCATCGTCTTGCTGAAC
TGACGATGAATAAACTGTATGACAAGATCCCGCCATCGGTCTGGAAATTCATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14349.14 Da        Isoelectric Point: 4.8989

>AT105005 WP_108704142.1 NZ_CP029128:1624616-1624990 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDIKLVTQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT105005 NZ_CP029128:1624616-1624990 [Klebsiella oxytoca]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTTAATGACCCAACCTCTGCTGTCAATCTTCAGCTTAATGAATTGATCGAGC
ACATTGCCGCGTTCGCACTTAATTATAAAATTAAGTATGCTGAGGATATTAAGCTGGTGACTCAGCTTGACGAATATCTG
GATGACACTTTCGTGTTGTTCAGCAACTACGGCATTAACACTGCAGATCTGCAGAAATGGCGTAAATCAGGCAACAGGTT
ATTCCGCTGCTTTGTGAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure

References