Detailed information of TA system TA105002

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 3864303..3865006
• Replicon: chromosome
• Accession: NZ_CP029126
• Organism: Enterobacter hormaechei strain AR432

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: CSC19_RS19095
• Protein ID: WP_062933997.1
• Coordinates: 3864665..3865006 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: CSC19_RS19090
• Protein ID: WP_062933996.1
• Coordinates: 3864303..3864644 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC19_RS19050	3859840..3860544	+	705	WP_062933990.1	WYL domain-containing protein	-
CSC19_RS19055	3860544..3861113	+	570	WP_062933991.1	hypothetical protein	-
CSC19_RS19060	3861150..3861602	+	453	WP_062933992.1	hypothetical protein	-
CSC19_RS19065	3861599..3862048	+	450	WP_062933993.1	hypothetical protein	-
CSC19_RS19070	3862120..3862343	+	224	Protein_3620	DUF905 domain-containing protein	-
CSC19_RS19075	3862442..3863263	+	822	WP_062933994.1	DUF945 domain-containing protein	-
CSC19_RS19080	3863294..3863737	+	444	WP_062933995.1	antirestriction protein	-
CSC19_RS19085	3863750..3864292	+	543	WP_080461297.1	DNA repair protein RadC	-
CSC19_RS19090	3864303..3864644	+	342	WP_062933996.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
CSC19_RS19095	3864665..3865006	+	342	WP_062933997.1	TA system toxin CbtA family protein	Toxin
CSC19_RS19100	3865265..3866272	+	1008	WP_032439165.1	restriction endonuclease	-
CSC19_RS19105	3866453..3867322	-	870	WP_045141660.1	HNH endonuclease	-
CSC19_RS19110	3867622..3868089	+	468	WP_074132654.1	SymE family type I addiction module toxin	-
CSC19_RS19115	3868257..3868787	+	531	WP_045141659.1	DUF2778 domain-containing protein	-
CSC19_RS19120	3868762..3869025	+	264	WP_045141658.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	fosA	-	3837197..3871731	34534

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-109)

Antitoxin

• Antitoxin CbeA (13-111)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12749.70 Da
• Isoelectric Point: 8.0324

>T105002 WP_062933997.1 NZ_CP029126:3864665-3865006 [Enterobacter hormaechei]
MKTLPATNLQAATLCLSPVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVRIDRRGF
DWQEQSPYLRAVDILRARQATGLLKRNRISAAR

Nucleotide

• Length: 342 bp

>T105002 NZ_CP029126:3864665-3865006 [Enterobacter hormaechei]
ATGAAAACTCTACCTGCAACAAATCTGCAGGCGGCGACGCTATGTCTGTCACCCGTGGCAGTCTGGCAAATGCTGCTTGC
ACGCCTGCTGGAACAACATTATGGCCTGACACTCAACGACACACCATTCAGTGATGAAACGGTAATTCAGGAACATATCG
ATGCCGGTATATCTTTGGCCGATGCCGTTAATTTTCTGGTGGAAAAGTACGGGCTGGTTCGTATTGATCGCAGGGGATTC
GACTGGCAAGAACAGTCCCCATATCTGCGGGCAGTCGATATTCTGCGGGCGCGACAGGCAACTGGTTTATTGAAAAGAAA
TCGTATTAGCGCGGCACGGTGA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12738.41 Da
• Isoelectric Point: 6.7300

>AT105002 WP_062933996.1 NZ_CP029126:3864303-3864644 [Enterobacter hormaechei]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGKFSEAECLRLDAAFPHFICQMESMLTTGEMNPRH
AHCVTLYHNGFTCEADTLGSCGYVYIAVYPTHR

Nucleotide

• Length: 342 bp

>AT105002 NZ_CP029126:3864303-3864644 [Enterobacter hormaechei]
ATGAAATCTACTGACTCAGAGAACGATTCATTTCTCAAGTGGGGTCTGAATCGTAATGTGACACCTTGCTTTGGCGCTCG
TCTGGTACAGGAGGGAAACCGACTGCACTATTTGGCTGACCGGGCCAGTATCACCGGTAAGTTCAGCGAAGCAGAATGTC
TTAGGCTGGATGCGGCATTCCCGCATTTTATCTGCCAGATGGAATCGATGCTGACTACTGGTGAAATGAATCCTCGCCAT
GCCCACTGTGTCACCCTGTACCACAATGGTTTCACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGC
CGTTTACCCCACTCATCGTTAA