104998

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2164054..2164711 Replicon chromosome
Accession NZ_CP029126
Organism Enterobacter hormaechei strain AR432

Toxin (Protein)


Gene name cptA Uniprot ID A0A179PSF7
Locus tag CSC19_RS10695 Protein ID WP_017382887.1
Coordinates 2164054..2164464 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag CSC19_RS10700 Protein ID WP_003863437.1
Coordinates 2164445..2164711 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC19_RS10675 2160052..2161785 - 1734 WP_045141946.1 single-stranded-DNA-specific exonuclease RecJ -
CSC19_RS10680 2161791..2162504 - 714 WP_003863443.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
CSC19_RS10685 2162533..2163429 - 897 WP_003863442.1 site-specific tyrosine recombinase XerD -
CSC19_RS10690 2163531..2164052 + 522 WP_015571793.1 flavodoxin FldB -
CSC19_RS10695 2164054..2164464 - 411 WP_017382887.1 protein YgfX Toxin
CSC19_RS10700 2164445..2164711 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
CSC19_RS10705 2165006..2165986 + 981 WP_017382888.1 tRNA-modifying protein YgfZ -
CSC19_RS10710 2166098..2166757 - 660 WP_003863433.1 hemolysin III family protein -
CSC19_RS10715 2167024..2167755 + 732 WP_015571796.1 MurR/RpiR family transcriptional regulator -
CSC19_RS10720 2167872..2169305 + 1434 WP_017382891.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16321.21 Da        Isoelectric Point: 11.4775

>T104998 WP_017382887.1 NZ_CP029126:c2164464-2164054 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAALVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWEMMGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Download         Length: 411 bp

>T104998 NZ_CP029126:c2164464-2164054 [Enterobacter hormaechei]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGGCTGGTGGCGGC
ACTGGTGTTATTGGTGCCGTGGCCGCTTAGCTATACCCCTCTGTGGTTGCTATTGCTGTCGTTTGTGGTGTTTGACAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAGATGATGGGGACGCCGTGGATGCTTAATACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCTGCGGAGTGGCGAGATCTGCGCCGGTTGATCGTGCAACAGCCGA
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT104998 WP_003863437.1 NZ_CP029126:c2164711-2164445 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT104998 NZ_CP029126:c2164711-2164445 [Enterobacter hormaechei]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A179PSF7

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References