Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4579808..4580852 Replicon chromosome
Accession NZ_CP029122
Organism Escherichia coli strain AR434

Toxin (Protein)


Gene name panT Uniprot ID A0A829CP20
Locus tag CSC21_RS23665 Protein ID WP_000019186.1
Coordinates 4579808..4580356 (-) Length 183 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID A0A839B6W4
Locus tag CSC21_RS23670 Protein ID WP_000287252.1
Coordinates 4580379..4580852 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC21_RS23620 4575020..4575571 - 552 WP_000515860.1 hypothetical protein -
CSC21_RS23625 4575615..4575815 - 201 WP_000649477.1 helix-turn-helix domain-containing protein -
CSC21_RS23630 4575906..4576580 + 675 WP_000859462.1 LexA family transcriptional repressor -
CSC21_RS23645 4577247..4577609 + 363 WP_000135682.1 hypothetical protein -
CSC21_RS23650 4577675..4578499 + 825 WP_001753751.1 DUF2303 family protein -
CSC21_RS23655 4578716..4579468 + 753 WP_001701368.1 hypothetical protein -
CSC21_RS23660 4579505..4579774 + 270 WP_001093912.1 pyocin activator PrtN family protein -
CSC21_RS23665 4579808..4580356 - 549 WP_000019186.1 hypothetical protein Toxin
CSC21_RS23670 4580379..4580852 - 474 WP_000287252.1 SocA family protein Antitoxin
CSC21_RS23675 4581139..4581261 - 123 WP_001300034.1 hypothetical protein -
CSC21_RS23680 4581624..4582640 - 1017 WP_000912595.1 DUF2713 family protein -
CSC21_RS23685 4582958..4583473 + 516 WP_001295691.1 zinc uptake transcriptional repressor Zur -
CSC21_RS23690 4583515..4583724 - 210 WP_001030593.1 CsbD family protein -
CSC21_RS23695 4583840..4585165 - 1326 WP_001301116.1 MATE family efflux transporter DinF -
CSC21_RS23700 4585238..4585846 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4557436..4585846 28410


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(27-123)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20026.39 Da        Isoelectric Point: 4.4481

>T104985 WP_000019186.1 NZ_CP029122:c4580356-4579808 [Escherichia coli]
MSHNSDIYKLIGAAAGVENGRSEASLNSTDSQEQAFESAFEPSNHERDDDSSSENKAILEEEEFGSNTGALHEFMQQNRM
DSLQAQLDMLKSQVRDKIADATGKEIDNELRTKMASFTVWFMSCWCLFVVAMFTSFLIAHEGKAPVEAIVALLGTSTISI
VGLVGFVVSGLFKSRKDSDKEK

Download         Length: 549 bp

>T104985 NZ_CP029122:c4580356-4579808 [Escherichia coli]
ATGTCTCATAATTCAGATATCTATAAACTGATCGGAGCGGCCGCAGGTGTTGAAAATGGTCGCTCTGAAGCATCCTTAAA
CTCTACTGACAGTCAAGAGCAGGCTTTTGAATCCGCATTTGAGCCGTCTAATCATGAACGCGATGATGATTCTTCTTCAG
AAAATAAGGCTATTCTGGAGGAAGAAGAGTTTGGTTCTAATACTGGTGCATTGCATGAGTTTATGCAGCAGAACAGAATG
GACAGTCTTCAAGCTCAGCTTGATATGCTCAAATCACAAGTACGGGATAAGATAGCTGACGCAACTGGTAAAGAAATAGA
CAATGAGCTCCGGACAAAAATGGCATCATTCACGGTTTGGTTTATGTCGTGTTGGTGCTTATTCGTTGTCGCAATGTTTA
CATCGTTTCTTATTGCACATGAAGGAAAGGCTCCAGTTGAAGCGATCGTTGCATTACTAGGTACAAGTACAATTAGTATT
GTTGGTTTGGTTGGTTTCGTTGTTAGTGGATTGTTCAAATCAAGAAAAGATAGTGATAAAGAAAAATAA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17298.80 Da        Isoelectric Point: 8.4143

>AT104985 WP_000287252.1 NZ_CP029122:c4580852-4580379 [Escherichia coli]
MYSPVQIANKFITLGNQHHNPLTHMQLQKLTYIAHGYYLALTGKPLLNECVSAWKYGPVIPGMYDAFKDYGNKPVTNVAV
APFGGIVTMDPQAESIIGAVYKFYGSKNGIELSTLTHMPGTPWSQAYNGIGSSIISNDAIKAYYHDLLNNRQQCQGL

Download         Length: 474 bp

>AT104985 NZ_CP029122:c4580852-4580379 [Escherichia coli]
ATGTACAGTCCGGTACAAATAGCCAATAAATTCATAACGTTGGGAAACCAACATCATAATCCTCTGACCCACATGCAACT
GCAGAAGCTTACTTATATTGCCCATGGTTACTATTTAGCATTAACAGGTAAGCCTTTGCTCAATGAATGTGTCTCCGCGT
GGAAGTACGGTCCAGTTATTCCTGGAATGTACGATGCTTTCAAAGACTATGGGAATAAACCTGTTACGAATGTAGCAGTA
GCTCCTTTTGGTGGCATCGTTACTATGGATCCGCAAGCAGAGAGCATTATCGGGGCTGTTTATAAGTTTTACGGCTCGAA
AAATGGAATTGAGTTATCAACTCTAACTCATATGCCAGGTACGCCTTGGTCACAAGCTTATAATGGTATTGGCTCGTCGA
TCATCTCAAATGATGCGATCAAGGCTTATTATCATGATTTATTGAATAACCGACAGCAATGTCAGGGCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CP20

Antitoxin

Source ID Structure
AlphaFold DB A0A839B6W4

References