Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 56743..57290 Replicon plasmid unnamed2
Accession NZ_CP029110
Organism Escherichia coli strain AR436

Toxin (Protein)


Gene name parE Uniprot ID W0LWB3
Locus tag CSC23_RS00345 Protein ID WP_000970007.1
Coordinates 57009..57290 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID E1QMW3
Locus tag CSC23_RS00340 Protein ID WP_000079941.1
Coordinates 56743..57012 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC23_RS00290 52101..52754 - 654 WP_106087059.1 conjugal transfer protein TraC -
CSC23_RS00305 53362..53649 - 288 WP_000074849.1 conjugal transfer protein TraA -
CSC23_RS00310 53567..53830 - 264 WP_001324596.1 ash family protein -
CSC23_RS00325 54803..55834 + 1032 WP_000907873.1 replication initiation protein -
CSC23_RS26005 56530..56688 + 159 WP_000841008.1 hypothetical protein -
CSC23_RS00340 56743..57012 + 270 WP_000079941.1 hypothetical protein Antitoxin
CSC23_RS00345 57009..57290 + 282 WP_000970007.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSC23_RS00350 57330..58178 + 849 WP_001057991.1 3'-5' exonuclease -
CSC23_RS00355 58295..58768 + 474 WP_001334658.1 hypothetical protein -
CSC23_RS26275 59245..59511 - 267 WP_000955263.1 hypothetical protein -
CSC23_RS00370 59511..60005 - 495 WP_001459505.1 hypothetical protein -
CSC23_RS00375 60061..60663 - 603 WP_000517695.1 hypothetical protein -
CSC23_RS00385 61017..61901 + 885 Protein_63 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCMY-2 - 1..91246 91246


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10892.63 Da        Isoelectric Point: 9.7617

>T104904 WP_000970007.1 NZ_CP029110:57009-57290 [Escherichia coli]
MMEIFWTMLASQDRKRIRKYIAEQNLMAAIELDERIGYSASSLAGQPYKGRNGRVEGTRELVIHPHFVLVYEVDSQWGKV
YILRVLHTAQKWP

Download         Length: 282 bp

>T104904 NZ_CP029110:57009-57290 [Escherichia coli]
ATGATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTAAGTACATTGCGGAGCAGAACCTGAT
GGCCGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTC
GTGTGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTG
TATATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10252.58 Da        Isoelectric Point: 7.2057

>AT104904 WP_000079941.1 NZ_CP029110:56743-57012 [Escherichia coli]
MAQVNMSLRIDAELKDAFMAAAKSMDRNGSQLIRDFMRQTVERQHNTWFRDQVEAGRQQLERGDVLPHDMVESSAAAWRD
EMSRKVAGK

Download         Length: 270 bp

>AT104904 NZ_CP029110:56743-57012 [Escherichia coli]
ATGGCACAGGTTAATATGAGTTTAAGAATCGACGCTGAACTGAAGGATGCTTTTATGGCCGCTGCAAAAAGCATGGACCG
TAATGGCTCTCAGTTAATTCGGGATTTTATGCGCCAGACCGTTGAACGGCAGCATAATACCTGGTTCCGTGACCAGGTTG
AGGCAGGACGTCAGCAACTCGAGCGCGGCGATGTGCTTCCCCATGACATGGTCGAATCTTCCGCTGCTGCATGGCGGGAT
GAAATGAGCAGGAAGGTTGCCGGTAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7G1GDN5

Antitoxin

Source ID Structure
AlphaFold DB A0A629TXC5

References