Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 188613..189529 Replicon plasmid unnamed2
Accession NZ_CP029096
Organism Pseudomonas aeruginosa strain AR439

Toxin (Protein)


Gene name slvT Uniprot ID A0A2L1KI32
Locus tag CSC26_RS01000 Protein ID WP_019437783.1
Coordinates 188613..189137 (-) Length 175 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A2L1KH13
Locus tag CSC26_RS01005 Protein ID WP_019437782.1
Coordinates 189134..189529 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC26_RS00975 184048..185133 + 1086 WP_033997868.1 helix-turn-helix domain-containing protein -
CSC26_RS00980 185258..186403 + 1146 WP_033997865.1 glycerate kinase -
CSC26_RS00985 186498..186752 - 255 WP_033997862.1 hypothetical protein -
CSC26_RS00990 186821..187012 - 192 WP_033997860.1 hypothetical protein -
CSC26_RS00995 187317..188567 + 1251 WP_019437784.1 TerD family protein -
CSC26_RS01000 188613..189137 - 525 WP_019437783.1 RES family NAD+ phosphorylase Toxin
CSC26_RS01005 189134..189529 - 396 WP_019437782.1 hypothetical protein Antitoxin
CSC26_RS01010 190114..191997 - 1884 WP_100247856.1 helicase -
CSC26_RS01015 192320..193348 - 1029 WP_034023821.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul1 / qacE / ant(3'')-Ia / blaIMP-18 / aac(6')-Il - 1..437392 437392
- flank IS/Tn - - 192320..193348 1028


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(10-167)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 175 a.a.        Molecular weight: 19052.57 Da        Isoelectric Point: 4.5535

>T104844 WP_019437783.1 NZ_CP029096:c189137-188613 [Pseudomonas aeruginosa]
MKIIGVQDLPCYRMHTPKWSVAPTSGAGAATQGGRVNRKGLEALYLSLESATAIAEFQQASAFLPPGLLISYSLSLDRVI
DFTGGYNDTWAPIWQDFFCDWRKIRFNDGVEPPSWIIGDLAIEADCAGILFESVANPGGRNLVLFTDQLPVHGNIVVNDP
RGDLPTDQSSWTRP

Download         Length: 525 bp

>T104844 NZ_CP029096:c189137-188613 [Pseudomonas aeruginosa]
ATGAAAATCATCGGAGTGCAGGACCTCCCCTGCTACCGAATGCACACTCCCAAGTGGTCCGTTGCGCCTACATCTGGAGC
TGGAGCTGCAACTCAGGGTGGCCGGGTTAACCGAAAGGGGCTAGAGGCTCTATACCTCTCGCTTGAGTCGGCAACGGCCA
TTGCTGAGTTTCAGCAAGCAAGCGCATTCCTTCCTCCTGGTCTGCTGATCAGCTATTCCCTCAGTCTGGATCGAGTGATC
GACTTCACCGGCGGCTATAACGATACCTGGGCCCCGATCTGGCAAGACTTCTTCTGCGACTGGAGAAAGATTCGCTTCAA
CGACGGCGTTGAACCGCCGAGCTGGATTATCGGGGATCTGGCTATCGAGGCTGACTGTGCTGGGATTCTGTTCGAGTCCG
TTGCGAACCCTGGAGGTCGGAACCTGGTGCTTTTCACCGATCAGTTGCCGGTGCATGGGAATATTGTGGTCAACGATCCT
CGCGGGGATCTCCCTACCGACCAGTCATCTTGGACGCGCCCGTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14753.87 Da        Isoelectric Point: 7.2048

>AT104844 WP_019437782.1 NZ_CP029096:c189529-189134 [Pseudomonas aeruginosa]
MASKAVLELRPTNFAGLMDALKEVNRVMFSPERFLKVFSMDQQTLALRAHVHRNTVRNAPESEKVQAYIRDSVKVLRAVT
DMGTDVTNAIFWFKNEPLSTFGYKTAEEVVSEGKTEQLIAFLQSWEAGAQG

Download         Length: 396 bp

>AT104844 NZ_CP029096:c189529-189134 [Pseudomonas aeruginosa]
ATGGCCAGCAAAGCCGTATTAGAGCTTCGCCCCACCAACTTCGCGGGCTTGATGGACGCTCTCAAAGAGGTGAACCGTGT
GATGTTCTCTCCTGAGCGCTTCCTCAAGGTTTTTTCGATGGACCAGCAGACCTTGGCGCTCCGGGCCCATGTCCATCGCA
ACACTGTGCGCAACGCGCCTGAATCGGAAAAGGTCCAGGCCTACATTCGTGATTCAGTGAAGGTTCTGCGCGCAGTGACC
GACATGGGCACGGACGTGACGAATGCCATCTTCTGGTTTAAGAACGAGCCTCTTTCCACGTTCGGCTATAAGACCGCGGA
GGAAGTGGTCAGCGAAGGAAAAACCGAGCAGCTGATCGCTTTCCTTCAATCTTGGGAAGCTGGTGCCCAAGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L1KI32

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1KH13

References