Detailed information of TA system TA104843

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): slvAT/RES(toxin)
• Location: 364467..365383
• Replicon: plasmid unnamed3
• Accession: NZ_CP029094
• Organism: Pseudomonas aeruginosa strain AR441

Toxin (Protein)

• Gene name: slvT
• Uniprot ID: A0A2I0C753
• Locus tag: CSC28_RS35110
• Protein ID: WP_058131799.1
• Coordinates: 364859..365383 (+)
• Length: 175 a.a.

Antitoxin (Protein)

• Gene name: slvA
• Uniprot ID: A0A8I0VVK2
• Locus tag: CSC28_RS35105
• Protein ID: WP_058178514.1
• Coordinates: 364467..364862 (+)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC28_RS35900	360115..360639	-	525	WP_123809559.1	hypothetical protein	-
CSC28_RS35100	361962..363881	+	1920	WP_079977411.1	helicase	-
CSC28_RS35105	364467..364862	+	396	WP_058178514.1	hypothetical protein	Antitoxin
CSC28_RS35110	364859..365383	+	525	WP_058131799.1	RES family NAD+ phosphorylase	Toxin
CSC28_RS35115	365429..366679	-	1251	WP_058131797.1	TerD family protein	-
CSC28_RS35120	367077..367268	+	192	WP_058131795.1	hypothetical protein	-
CSC28_RS35130	367689..368834	-	1146	WP_058178512.1	glycerate kinase	-
CSC28_RS35135	368959..370044	-	1086	WP_021263239.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..438529	438529

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 175 a.a.
• Molecular weight: 22448.48 Da
• Isoelectric Point: 13.0405

>T104843 WP_058131799.1 NZ_CP029094:364859-365383 [Pseudomonas aeruginosa]
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Nucleotide

• Length: 525 bp

>T104843 NZ_CP029094:364859-365383 [Pseudomonas aeruginosa]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
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AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 16937.00 Da
• Isoelectric Point: 12.9172

>AT104843 WP_058178514.1 NZ_CP029094:364467-364862 [Pseudomonas aeruginosa]
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KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK

Nucleotide

• Length: 396 bp

>AT104843 NZ_CP029094:364467-364862 [Pseudomonas aeruginosa]
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

Structures

Toxin

• AlphaFold DB: A0A2I0C753