104841

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 7167287..7167944 Replicon chromosome
Accession NZ_CP029090
Organism Pseudomonas aeruginosa strain AR442

Toxin (Protein)


Gene name hicA Uniprot ID A0A8G3IXE4
Locus tag CSC29_RS35030 Protein ID WP_003098540.1
Coordinates 7167762..7167944 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag CSC29_RS35025 Protein ID WP_003124172.1
Coordinates 7167287..7167715 (-) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC29_RS34995 7162897..7163127 + 231 WP_023124259.1 hypothetical protein -
CSC29_RS35000 7163124..7163963 + 840 WP_033944546.1 helix-turn-helix domain-containing protein -
CSC29_RS35005 7163875..7164759 + 885 WP_191984976.1 ATP-binding protein -
CSC29_RS35010 7164756..7166153 + 1398 WP_033944544.1 AAA family ATPase -
CSC29_RS35015 7166150..7166434 + 285 WP_023835928.1 hypothetical protein -
CSC29_RS35020 7166431..7166988 + 558 WP_015980945.1 hypothetical protein -
CSC29_RS35025 7167287..7167715 - 429 WP_003124172.1 hypothetical protein Antitoxin
CSC29_RS35030 7167762..7167944 - 183 WP_003098540.1 type II toxin-antitoxin system HicA family toxin Toxin
CSC29_RS35035 7168145..7168459 + 315 WP_015649339.1 phage holin, lambda family -
CSC29_RS35040 7168459..7169076 + 618 WP_023465046.1 glycoside hydrolase family 19 protein -
CSC29_RS35045 7169076..7169546 + 471 WP_023465047.1 lysis system i-spanin subunit Rz -
CSC29_RS35050 7169543..7170286 + 744 WP_023835830.1 hypothetical protein -
CSC29_RS35055 7170438..7170983 + 546 WP_003159067.1 terminase small subunit -
CSC29_RS35060 7170955..7172919 + 1965 WP_023086966.1 phage terminase large subunit family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-78)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6746.86 Da        Isoelectric Point: 11.0775

>T104841 WP_003098540.1 NZ_CP029090:c7167944-7167762 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGAKEMPEPTRKAIIKQLGLK

Download         Length: 183 bp

>T104841 NZ_CP029090:c7167944-7167762 [Pseudomonas aeruginosa]
ATGAAGTTCAGCGAATTCAGACGATGGTTGAAGGCCCAAGGGGTGACCTTCGAAGCCGGCAAGGGAAGCCACTTCAAGAT
CACCGCCCCGAACGGCAAACAGACCACCTTCGCGGACCACGGAGCTAAGGAAATGCCAGAACCGACCCGCAAGGCGATCA
TCAAGCAACTGGGGCTCAAATGA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15770.97 Da        Isoelectric Point: 4.6562

>AT104841 WP_003124172.1 NZ_CP029090:c7167715-7167287 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKAHAISEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KVALWNEMIRRDMRKADLCRLLGIAQIQGDRLVDFLHNTKMEAMENALSALGLRLSVNIEAA

Download         Length: 429 bp

>AT104841 NZ_CP029090:c7167715-7167287 [Pseudomonas aeruginosa]
ATGTACGACTATGCAATCCGTTTCGAACAGGACGATAGCGCTCCTGGCGTCGCCGTTTTCTGCAGAGACCTGCCGGAACT
GAACAGCTACGGCGACGATAAGGCCCATGCAATCAGCGAGGCGGTTGACGCCATCGAGTCAACCCTCTCGCTGTACGTTG
ATCAGCGCCGAGAAATCCCCGCAGCCAGCCAGGCACAACCAGGCGAGCGCGTTATCCATCTGCCGGCGGTTACCGTTGCG
AAGGTCGCGCTCTGGAACGAAATGATCCGTCGAGATATGCGAAAAGCTGACCTCTGCCGGCTCCTCGGGATCGCGCAGAT
CCAGGGTGACAGGCTCGTCGACTTCCTCCACAACACCAAGATGGAAGCCATGGAGAACGCGCTATCCGCCCTCGGCCTCC
GCCTATCAGTGAATATCGAGGCGGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References