Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/RHH(antitoxin)
Location 1680485..1681038 Replicon chromosome
Accession NZ_CP029090
Organism Pseudomonas aeruginosa strain AR442

Toxin (Protein)


Gene name parE Uniprot ID Q88JZ3
Locus tag CSC29_RS08390 Protein ID WP_010953434.1
Coordinates 1680745..1681038 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q88JZ4
Locus tag CSC29_RS08385 Protein ID WP_010953433.1
Coordinates 1680485..1680757 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC29_RS08355 1676057..1676416 - 360 Protein_1623 DNA repair protein RadC -
CSC29_RS08360 1676388..1677338 - 951 WP_031299400.1 hypothetical protein -
CSC29_RS08365 1677431..1678435 - 1005 WP_010953429.1 YqaJ viral recombinase family protein -
CSC29_RS08370 1678515..1679483 - 969 WP_031299399.1 DUF932 domain-containing protein -
CSC29_RS08375 1679581..1679853 - 273 WP_031299398.1 hypothetical protein -
CSC29_RS08380 1680115..1680360 + 246 WP_010953432.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
CSC29_RS08385 1680485..1680757 + 273 WP_010953433.1 CopG family ribbon-helix-helix protein Antitoxin
CSC29_RS08390 1680745..1681038 + 294 WP_010953434.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSC29_RS08395 1681032..1682441 - 1410 WP_010953435.1 site-specific integrase -
CSC29_RS08400 1682879..1685659 + 2781 WP_023464835.1 DEAD/DEAH box helicase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1651070..1703507 52437


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-95)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11155.61 Da        Isoelectric Point: 5.9081

>T104835 WP_010953434.1 NZ_CP029090:1680745-1681038 [Pseudomonas aeruginosa]
VPRLIVTEGAAKGLERCRRFLSDKDPQVARRAAQAIERQFARLEESPEVGRPFPDLPELRELIIEFGDSGYVALYRYERA
DDTAYVLAFRHQKEAGY

Download         Length: 294 bp

>T104835 NZ_CP029090:1680745-1681038 [Pseudomonas aeruginosa]
GTGCCACGACTGATCGTCACTGAAGGCGCGGCGAAGGGCCTGGAGCGTTGCCGGCGATTTCTCTCCGATAAAGATCCGCA
GGTCGCACGCCGTGCTGCACAGGCAATCGAGCGCCAATTCGCTCGATTGGAGGAAAGTCCGGAAGTAGGGCGTCCTTTTC
CAGATCTGCCAGAGCTGCGTGAGCTCATCATCGAGTTTGGTGACTCAGGTTACGTCGCGCTGTACCGCTATGAGCGCGCA
GATGACACCGCCTATGTCTTGGCCTTTCGCCATCAAAAAGAAGCTGGCTACTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10373.53 Da        Isoelectric Point: 5.5744

>AT104835 WP_010953433.1 NZ_CP029090:1680485-1680757 [Pseudomonas aeruginosa]
MATSIKIDDDLKGRIQHLACLRQRSSHWIMREAITQYVEREEARESFKQEALASWAAYQETGQHLTGQEARTWLGSWGTD
AEAELPKCHD

Download         Length: 273 bp

>AT104835 NZ_CP029090:1680485-1680757 [Pseudomonas aeruginosa]
ATGGCCACTTCCATCAAAATTGACGACGATCTGAAAGGTCGCATTCAGCATTTGGCTTGTTTGCGCCAGCGCTCATCTCA
CTGGATCATGCGTGAGGCGATCACCCAGTACGTCGAGCGTGAGGAGGCCCGTGAGAGCTTCAAACAAGAAGCGCTGGCAT
CTTGGGCTGCATACCAGGAAACCGGCCAGCACTTGACCGGCCAGGAGGCTCGCACCTGGCTTGGTAGTTGGGGTACAGAT
GCTGAGGCAGAGTTACCCAAGTGCCACGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2W5CNE8

Antitoxin

Source ID Structure
AlphaFold DB Q88JZ4

References