Detailed information of TA system TA104828

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2869012..2869528
• Replicon: chromosome
• Accession: NZ_CP029089
• Organism: Pseudomonas aeruginosa strain AR444

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: CSC31_RS13445
• Protein ID: WP_071557699.1
• Coordinates: 2869012..2869293 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A482UCX2
• Locus tag: CSC31_RS13450
• Protein ID: WP_033942931.1
• Coordinates: 2869283..2869528 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC31_RS13415	2864175..2864393	-	219	WP_071557701.1	AlpA family transcriptional regulator	-
CSC31_RS13425	2865199..2866167	+	969	WP_033942925.1	DUF932 domain-containing protein	-
CSC31_RS13430	2866242..2867246	+	1005	WP_033942926.1	YqaJ viral recombinase family protein	-
CSC31_RS13435	2867339..2868250	+	912	WP_033942927.1	hypothetical protein	-
CSC31_RS13440	2868261..2868758	+	498	WP_033942928.1	DNA repair protein RadC	-
CSC31_RS13445	2869012..2869293	-	282	WP_071557699.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
CSC31_RS13450	2869283..2869528	-	246	WP_033942931.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
CSC31_RS32580	2869698..2870135	+	438	WP_033942934.1	hypothetical protein	-
CSC31_RS13455	2870053..2870511	-	459	Protein_2594	hypothetical protein	-
CSC31_RS13460	2870635..2873802	-	3168	WP_033942936.1	DEAD/DEAH box helicase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2849382..2892517	43135

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10721.55 Da
• Isoelectric Point: 10.6485

>T104828 WP_071557699.1 NZ_CP029089:c2869293-2869012 [Pseudomonas aeruginosa]
MTYKLEFLPSALKEWEKLGHTVREQAKKKLRERLEAPKVQADALRDLPGHYKIKLRTAGYRLVYNVEDDRVVVIVVAVGK
RERSAAYKAAGKR

Nucleotide

• Length: 282 bp

>T104828 NZ_CP029089:c2869293-2869012 [Pseudomonas aeruginosa]
ATGACCTATAAGCTCGAGTTCCTGCCCTCAGCGCTGAAGGAATGGGAGAAGCTGGGTCATACGGTGCGTGAGCAGGCAAA
GAAAAAACTGCGTGAGCGGCTGGAAGCACCAAAGGTACAGGCTGATGCCCTCAGGGATCTGCCTGGCCACTACAAGATCA
AGCTCCGAACAGCAGGCTATCGATTGGTCTATAATGTCGAGGATGATCGGGTGGTTGTGATTGTGGTCGCAGTGGGCAAG
CGTGAACGAAGTGCAGCTTACAAGGCAGCAGGTAAGCGTTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8653.98 Da
• Isoelectric Point: 4.1469

>AT104828 WP_033942931.1 NZ_CP029089:c2869528-2869283 [Pseudomonas aeruginosa]
MQSVLADVAVSVSELKKNPTGVMAGAGGMPVAVLNHNRVMGYMVPAELYEQMLDRLDDLDLIDVVNARSGEKGVPVNLDD
L

Nucleotide

• Length: 246 bp

>AT104828 NZ_CP029089:c2869528-2869283 [Pseudomonas aeruginosa]
ATGCAGAGTGTTTTGGCTGACGTTGCCGTGAGCGTTTCTGAGCTGAAGAAAAACCCCACCGGTGTCATGGCTGGTGCGGG
TGGCATGCCGGTCGCAGTTCTCAATCATAACCGCGTGATGGGGTACATGGTGCCAGCCGAGCTGTACGAGCAGATGTTGG
ACCGTTTGGACGATCTGGATCTGATCGATGTCGTTAACGCGCGCTCCGGTGAGAAGGGTGTGCCGGTGAACCTGGATGAC
CTATAA

Structures

Antitoxin

• AlphaFold DB: A0A482UCX2