Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2666199..2666715 Replicon chromosome
Accession NZ_CP029088
Organism Pseudomonas aeruginosa strain AR445

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag CSC32_RS13195 Protein ID WP_025297453.1
Coordinates 2666434..2666715 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag CSC32_RS13190 Protein ID WP_025297454.1
Coordinates 2666199..2666444 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC32_RS13170 2661321..2661650 - 330 WP_031692728.1 hypothetical protein -
CSC32_RS13175 2661998..2662666 + 669 WP_071534660.1 hypothetical protein -
CSC32_RS13180 2662663..2663769 + 1107 WP_025297456.1 XRE family transcriptional regulator -
CSC32_RS13185 2663900..2666041 + 2142 WP_025297455.1 hypothetical protein -
CSC32_RS13190 2666199..2666444 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CSC32_RS13195 2666434..2666715 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CSC32_RS13200 2667121..2667702 - 582 WP_033895412.1 plasmid pRiA4b ORF-3 family protein -
CSC32_RS13205 2667716..2668591 - 876 WP_033895413.1 WYL domain-containing protein -
CSC32_RS13210 2668726..2670300 + 1575 WP_025297452.1 DNA recombination protein RmuC -
CSC32_RS13215 2670324..2670972 + 649 Protein_2555 peptidase M15 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2649434..2691652 42218


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T104821 WP_025297453.1 NZ_CP029088:2666434-2666715 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

>T104821 NZ_CP029088:2666434-2666715 [Pseudomonas aeruginosa]
ATGACCTATGAGCTGGAGTTCCTGCCCTCAGCCCTGAAGGAGTGGCAGAAGCTCGGCCATACGGTGCGCGAGCAGATCAA
AAAGAAACTGCGCGAGCGCCTGGATAATCCCAAGGTTCAGGCCGACGCCCTCAGGGATATGCCGGGGCACTACAAAATCA
AGCTGCGTGCATCGGGCTATCGTCTGGTATACCGCGTCGAAGATGAGCGCGTGGTGGTCGTGGTGGTTGCCGTTGGCAAG
CGCGAGCGTGGGGCCGCTTACCAATCTGCCAAGGGCCGTTAG

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT104821 WP_025297454.1 NZ_CP029088:2666199-2666444 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp

>AT104821 NZ_CP029088:2666199-2666444 [Pseudomonas aeruginosa]
ATGCAGAGTATCTTGGCTGACGTCGCTGTCAGCGTTTCTGAGTTGAAGAAAAATCCGTCGGGCATCCTGGCTGGTGCAGG
TGGTATGCCTGTCGCCGTGCTCAACCACAATCGCGTCATGGGATACATGGTGCCGGCAGAGCTCTATGAGCAGATGATGG
AGCGCCTAGATGATCTGGAGTTGGTCGAAATAGTGAAGGCTCGCTCGGGCGAGGAGTCTGTCCCGGTGCGTTTGGATGAC
CTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References