Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rnlAB/RnlA-RnlB
Location 1168128..1169549 Replicon chromosome
Accession NZ_CP029088
Organism Pseudomonas aeruginosa strain AR445

Toxin (Protein)


Gene name rnlA Uniprot ID -
Locus tag CSC32_RS05770 Protein ID WP_025297643.1
Coordinates 1168476..1169549 (-) Length 358 a.a.

Antitoxin (Protein)


Gene name rnlB Uniprot ID -
Locus tag CSC32_RS05765 Protein ID WP_158025315.1
Coordinates 1168128..1168421 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC32_RS05720 1163231..1163443 + 213 WP_023128602.1 hypothetical protein -
CSC32_RS05725 1163534..1163989 - 456 WP_025297646.1 helix-turn-helix domain-containing protein -
CSC32_RS05730 1164154..1164549 + 396 WP_023128603.1 hypothetical protein -
CSC32_RS05735 1164592..1165062 + 471 WP_023128604.1 hypothetical protein -
CSC32_RS05740 1165065..1165448 + 384 WP_025297645.1 hypothetical protein -
CSC32_RS05745 1165530..1166108 + 579 WP_025297644.1 hypothetical protein -
CSC32_RS05750 1166439..1166803 + 365 Protein_1109 DNA binding protein -
CSC32_RS05755 1167027..1167221 - 195 WP_023128607.1 OprD family outer membrane porin -
CSC32_RS05760 1167220..1167915 + 696 WP_196747054.1 transporter substrate-binding domain-containing protein -
CSC32_RS05765 1168128..1168421 - 294 WP_158025315.1 type II toxin-antitoxin system RnlB family antitoxin Antitoxin
CSC32_RS05770 1168476..1169549 - 1074 WP_025297643.1 type II toxin-antitoxin system RnlA family toxin Toxin
CSC32_RS05775 1170264..1170518 + 255 WP_023128610.1 hypothetical protein -
CSC32_RS05785 1170816..1171112 + 297 WP_023128612.1 hypothetical protein -
CSC32_RS05790 1171165..1172748 - 1584 WP_025297642.1 hypothetical protein -
CSC32_RS05795 1173028..1173456 + 429 WP_025297641.1 S24 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Bacterial toxin, RNase RnlA/LsoA, N-terminal

(6-87)

Antitoxin

Antitoxin RnlB/LsoB

(2-96)


Sequences

Toxin        


Download         Length: 358 a.a.        Molecular weight: 40381.89 Da        Isoelectric Point: 6.1830

>T104819 WP_025297643.1 NZ_CP029088:c1169549-1168476 [Pseudomonas aeruginosa]
VTERDYKNINLKRCIIEETTHCFIRDNGLKLRSYGDKPGSSGLRVVFGKAGIEDATLDIFFTNVGASTLTYKVGKNQALG
QQLADALYETIHPDEFVTMNLGIKGVDLDDAEALIKELTESANADIEVASRTSADRKHIWKLKSKKNLDELTVTQHENTH
KLQIQGRPLSCYQQLSYLLTELLEINALECILFKKEENRSEFVCAEVAESVLKERFGDCYANLPQTSRRLLLASLCVRLA
SPALPDYCMLVYPELRTLEGAIKQKLAEKNLSNQEESFGGFFTKTNGQFYLKQQYHADVGDAKLQGHLDNAYTFFNKQRH
GLFHMEEMPSVSRMISNITQAVSLCDEAYDHIKNLYS

Download         Length: 1074 bp

>T104819 NZ_CP029088:c1169549-1168476 [Pseudomonas aeruginosa]
GTGACTGAACGCGACTACAAAAACATCAACCTCAAACGATGCATTATCGAGGAAACGACTCATTGCTTCATCCGAGATAA
TGGCCTGAAGCTGCGATCCTATGGTGACAAGCCTGGGAGTTCCGGTCTTCGAGTAGTCTTCGGAAAAGCAGGGATTGAAG
ATGCCACGCTTGATATTTTTTTCACGAATGTCGGTGCGTCTACCCTGACCTACAAGGTGGGCAAGAACCAAGCTCTCGGC
CAGCAGCTAGCGGATGCTCTTTACGAAACAATCCACCCCGATGAATTCGTAACGATGAACCTTGGTATCAAAGGCGTCGA
TCTGGATGATGCCGAAGCCCTTATCAAGGAACTCACTGAGTCAGCCAATGCGGACATTGAGGTTGCTTCGCGCACAAGCG
CTGATCGCAAGCATATTTGGAAGCTCAAGTCTAAAAAGAACTTGGATGAGTTGACTGTCACTCAGCACGAGAACACCCAT
AAACTGCAGATCCAGGGTCGTCCTCTCAGCTGCTATCAGCAGTTGAGCTACCTGCTCACCGAGCTCCTAGAGATCAACGC
ACTCGAATGCATCCTGTTCAAAAAGGAAGAAAATCGCTCGGAGTTCGTTTGTGCCGAGGTCGCGGAAAGCGTACTCAAGG
AAAGGTTTGGCGACTGCTACGCCAACCTGCCACAGACCTCGCGTAGGCTGCTCCTGGCAAGCCTTTGCGTGAGGCTTGCC
AGCCCCGCGCTACCCGACTACTGCATGCTGGTTTATCCGGAACTCCGCACCCTTGAAGGCGCGATCAAACAGAAGCTTGC
AGAAAAAAACCTTTCAAATCAGGAAGAAAGCTTCGGTGGCTTCTTTACCAAGACCAATGGTCAGTTTTATCTGAAGCAGC
AATACCATGCTGATGTCGGCGATGCTAAACTACAGGGTCATCTGGACAACGCTTACACCTTCTTCAACAAGCAACGCCAC
GGATTGTTCCACATGGAAGAGATGCCATCCGTTAGTCGAATGATTAGCAACATCACCCAAGCTGTGTCATTGTGTGATGA
AGCATATGATCATATCAAGAATTTGTATAGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11039.38 Da        Isoelectric Point: 4.5163

>AT104819 WP_158025315.1 NZ_CP029088:c1168421-1168128 [Pseudomonas aeruginosa]
MTVVTATSYENPLSRLSIIASEMRNTSHSSKEIVLFDLLCSNGEEWNRFVSINYNGTDFEKSTCSIVSKSDIPTDLLETQ
TRFFQIHPQYLLDSVLN

Download         Length: 294 bp

>AT104819 NZ_CP029088:c1168421-1168128 [Pseudomonas aeruginosa]
ATGACGGTAGTTACCGCTACCAGTTATGAGAACCCCTTATCTCGTCTTTCTATTATTGCTAGCGAGATGCGCAATACATC
TCACTCCAGCAAGGAGATAGTTCTATTCGATCTACTCTGCTCTAACGGAGAAGAGTGGAATCGTTTCGTCTCCATCAATT
ACAACGGCACCGACTTCGAAAAAAGCACCTGTAGCATTGTCTCCAAGTCCGACATCCCTACAGACCTCTTGGAAACACAA
ACTCGCTTCTTTCAAATCCATCCACAATATCTGCTTGATTCAGTTTTGAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References