Detailed information of TA system TA104818

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 160237..160742
• Replicon: chromosome
• Accession: NZ_CP029088
• Organism: Pseudomonas aeruginosa strain AR445

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: CSC32_RS00770
• Protein ID: WP_003083773.1
• Coordinates: 160237..160518 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: CSC32_RS00775
• Protein ID: WP_003083775.1
• Coordinates: 160515..160742 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CSC32_RS00745	155488..156837	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
CSC32_RS00750	156886..157572	+	687	WP_003083762.1	FadR family transcriptional regulator	-
CSC32_RS00755	157673..158407	+	735	WP_004346926.1	GntR family transcriptional regulator	-
CSC32_RS00760	158611..158997	+	387	WP_014602345.1	aegerolysin family protein	-
CSC32_RS00765	159029..159937	-	909	WP_003083769.1	LysR family transcriptional regulator	-
CSC32_RS00770	160237..160518	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
CSC32_RS00775	160515..160742	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
CSC32_RS00780	160918..161538	-	621	WP_003101226.1	hypothetical protein	-
CSC32_RS00785	161639..162139	+	501	WP_003101228.1	LEA type 2 family protein	-
CSC32_RS00790	162212..162553	+	342	WP_003101229.1	alkylphosphonate utilization protein	-
CSC32_RS00795	162635..164062	-	1428	WP_003083784.1	GABA permease	-
CSC32_RS00800	164231..165724	-	1494	WP_003083788.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T104818 WP_003083773.1 NZ_CP029088:c160518-160237 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T104818 NZ_CP029088:c160518-160237 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT104818 WP_003083775.1 NZ_CP029088:c160742-160515 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT104818 NZ_CP029088:c160742-160515 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9