Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2250552..2251066 Replicon chromosome
Accession NZ_CP029087
Organism Staphylococcus aureus strain AR461

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag CSC47_RS11865 Protein ID WP_000581792.1
Coordinates 2250552..2250761 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag CSC47_RS11870 Protein ID WP_000138932.1
Coordinates 2250773..2251066 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC47_RS11845 2246060..2247418 - 1359 WP_108711073.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
CSC47_RS11850 2247433..2248503 - 1071 WP_000159631.1 D-alanine--D-alanine ligase -
CSC47_RS11855 2248821..2250023 + 1203 WP_001109939.1 rod shape-determining protein RodA -
CSC47_RS11860 2250287..2250424 - 138 WP_000828354.1 hypothetical protein -
CSC47_RS11865 2250552..2250761 - 210 WP_000581792.1 heavy-metal-associated domain-containing protein Toxin
CSC47_RS11870 2250773..2251066 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
CSC47_RS11875 2251232..2252716 + 1485 WP_000571549.1 cardiolipin synthase -
CSC47_RS11880 2252744..2253391 + 648 WP_001187630.1 HD domain-containing protein -
CSC47_RS11905 2254304..2255176 - 873 WP_000725802.1 membrane protein insertase YidC -
CSC47_RS11910 2255262..2255903 - 642 WP_000483153.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T104811 WP_000581792.1 NZ_CP029087:c2250761-2250552 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T104811 NZ_CP029087:c2250761-2250552 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT104811 WP_000138932.1 NZ_CP029087:c2251066-2250773 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT104811 NZ_CP029087:c2251066-2250773 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References