Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 860478..860955 Replicon chromosome
Accession NZ_CP029087
Organism Staphylococcus aureus strain AR461

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSC47_RS04245 Protein ID WP_000052076.1
Coordinates 860478..860666 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSC47_RS04250 Protein ID WP_001059690.1
Coordinates 860695..860955 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC47_RS04215 856472..856993 + 522 WP_000824482.1 hypothetical protein -
CSC47_RS04220 857334..858020 + 687 WP_000141557.1 thermonuclease family protein -
CSC47_RS04225 858377..858577 + 201 WP_001059082.1 cold-shock protein -
CSC47_RS04230 859069..859287 - 219 WP_000005886.1 hypothetical protein -
CSC47_RS04235 859349..859633 - 285 WP_001004399.1 hypothetical protein -
CSC47_RS04240 859721..860290 - 570 WP_001106658.1 hypothetical protein -
CSC47_RS04245 860478..860666 - 189 WP_000052076.1 hypothetical protein Toxin
CSC47_RS04250 860695..860955 - 261 WP_001059690.1 hypothetical protein Antitoxin
CSC47_RS04255 861296..861499 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSC47_RS04260 861496..861732 - 237 WP_000349581.1 hypothetical protein -
CSC47_RS04265 861957..862538 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
CSC47_RS04270 862611..863228 - 618 WP_000255551.1 LysE/ArgO family amino acid transporter -
CSC47_RS04275 863383..863877 - 495 WP_000569883.1 GNAT family N-acetyltransferase -
CSC47_RS04280 864276..864698 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSC47_RS04285 864846..865562 + 717 WP_000150011.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T104800 WP_000052076.1 NZ_CP029087:c860666-860478 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T104800 NZ_CP029087:c860666-860478 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT104800 WP_001059690.1 NZ_CP029087:c860955-860695 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT104800 NZ_CP029087:c860955-860695 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References