Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2174041..2174518 Replicon chromosome
Accession NZ_CP029086
Organism Staphylococcus aureus strain AR462

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag CSC48_RS11355 Protein ID WP_000052076.1
Coordinates 2174041..2174229 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag CSC48_RS11360 Protein ID WP_001059690.1
Coordinates 2174258..2174518 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC48_RS11325 2170035..2170556 + 522 WP_000824482.1 hypothetical protein -
CSC48_RS11330 2170897..2171583 + 687 WP_000141557.1 thermonuclease family protein -
CSC48_RS11335 2171940..2172140 + 201 WP_001059082.1 cold-shock protein -
CSC48_RS11340 2172632..2172850 - 219 WP_000005886.1 hypothetical protein -
CSC48_RS11345 2172912..2173196 - 285 WP_001004399.1 hypothetical protein -
CSC48_RS11350 2173284..2173853 - 570 WP_001106654.1 hypothetical protein -
CSC48_RS11355 2174041..2174229 - 189 WP_000052076.1 hypothetical protein Toxin
CSC48_RS11360 2174258..2174518 - 261 WP_001059690.1 hypothetical protein Antitoxin
CSC48_RS11365 2174859..2175062 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
CSC48_RS11370 2175059..2175295 - 237 WP_000349581.1 hypothetical protein -
CSC48_RS11375 2175520..2176101 + 582 WP_001140693.1 phosphoglycerate mutase family protein -
CSC48_RS11380 2176174..2176791 - 618 WP_108720573.1 LysE/ArgO family amino acid transporter -
CSC48_RS11385 2176946..2177440 - 495 WP_023913577.1 GNAT family N-acetyltransferase -
CSC48_RS11390 2177839..2178261 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
CSC48_RS11395 2178409..2179125 + 717 WP_108720574.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(11-71)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T104799 WP_000052076.1 NZ_CP029086:c2174229-2174041 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T104799 NZ_CP029086:c2174229-2174041 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT104799 WP_001059690.1 NZ_CP029086:c2174518-2174258 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT104799 NZ_CP029086:c2174518-2174258 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References