104791

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 656537..657066 Replicon chromosome
Accession NZ_CP029086
Organism Staphylococcus aureus strain AR462

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag CSC48_RS03650 Protein ID WP_000621175.1
Coordinates 656537..656899 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag CSC48_RS03655 Protein ID WP_000948331.1
Coordinates 656896..657066 (-) Length 57 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CSC48_RS03625 653515..654285 - 771 WP_001041111.1 RNA polymerase sigma factor SigB -
CSC48_RS03630 654260..654739 - 480 WP_001190829.1 anti-sigma B factor RsbW -
CSC48_RS03635 654741..655067 - 327 WP_001052491.1 anti-sigma factor antagonist -
CSC48_RS03640 655186..656187 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
CSC48_RS03650 656537..656899 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
CSC48_RS03655 656896..657066 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
CSC48_RS03660 657151..658299 - 1149 WP_001281154.1 alanine racemase -
CSC48_RS03665 658365..658724 - 360 WP_000581197.1 holo-ACP synthase -
CSC48_RS03670 658728..659219 - 492 WP_001205912.1 PH domain-containing protein -
CSC48_RS03675 659206..660789 - 1584 WP_001294626.1 PH domain-containing protein -
CSC48_RS03680 660782..661261 - 480 WP_001287087.1 hypothetical protein -
CSC48_RS03685 661469..662029 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-110)

Antitoxin


No domain identified.



Sequences


Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T104791 WP_000621175.1 NZ_CP029086:c656899-656537 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T104791 NZ_CP029086:c656899-656537 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT104791 WP_000948331.1 NZ_CP029086:c657066-656896 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT104791 NZ_CP029086:c657066-656896 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References